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KLF9 Kruppel like factor 9 [ Homo sapiens (human) ]

Gene ID: 687, updated on 6-Dec-2016
Official Symbol
KLF9provided by HGNC
Official Full Name
Kruppel like factor 9provided by HGNC
Primary source
HGNC:HGNC:1123
See related
Ensembl:ENSG00000119138 MIM:602902; Vega:OTTHUMG00000019991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTEB; BTEB1
Summary
The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]
Orthologs
Location:
9q21.12
Exon count:
2
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (70384597..70414657, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (72999513..73029573, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene MAM domain containing 2 Neighboring gene SMC5 antisense RNA 1 (head to head) Neighboring gene ribosomal protein L24 pseudogene 8 Neighboring gene structural maintenance of chromosomes 5 Neighboring gene uncharacterized LOC101927086 Neighboring gene uncharacterized LOC105376079 Neighboring gene RNA, 7SL, cytoplasmic 726, pseudogene Neighboring gene transient receptor potential cation channel subfamily M member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat BTEB enhances HIV-1 Tat transactivation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystem (from WikiPathways)
    Diurnally Regulated Genes with Circadian Orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to cortisol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to thyroid hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
Krueppel-like factor 9
Names
BTE-binding protein 1
GC-box-binding protein 1
basic transcription element-binding protein 1
transcription factor BTEB1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206.2NP_001197.1  Krueppel-like factor 9

    See identical proteins and their annotated locations for NP_001197.1

    Status: REVIEWED

    Source sequence(s)
    AI458659, AI693223, AL162390, BC069431, BE221978
    Consensus CDS
    CCDS6633.1
    UniProtKB/Swiss-Prot
    Q13886
    UniProtKB/TrEMBL
    A0A024R260
    Related
    ENSP00000366330, OTTHUMP00000021441, ENST00000377126, OTTHUMT00000052602
    Conserved Domains (4) summary
    COG5048
    Location:94234
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:145167
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:203225
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:189212
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

    Range
    70384597..70414657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    73146053..73176110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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