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KLF9 Kruppel like factor 9 [ Homo sapiens (human) ]

Gene ID: 687, updated on 10-May-2020

Summary

Official Symbol
KLF9provided by HGNC
Official Full Name
Kruppel like factor 9provided by HGNC
Primary source
HGNC:HGNC:1123
See related
Ensembl:ENSG00000119138 MIM:602902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTEB; BTEB1
Summary
The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 44.7), gall bladder (RPKM 34.1) and 25 other tissues See more
Orthologs

Genomic context

See KLF9 in Genome Data Viewer
Location:
9q21.12
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (70384597..70414657, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (72999513..73029573, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene MAM domain containing 2 Neighboring gene SMC5 antisense RNA 1 (head to head) Neighboring gene RPL24 pseudogene 8 Neighboring gene structural maintenance of chromosomes 5 Neighboring gene Sharpr-MPRA regulatory region 12362 Neighboring gene KLF9 divergent transcript Neighboring gene uncharacterized LOC105376079

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat BTEB enhances HIV-1 Tat transactivation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to cortisol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to thyroid hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
Krueppel-like factor 9
Names
BTE-binding protein 1
GC-box-binding protein 1
basic transcription element-binding protein 1
transcription factor BTEB1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206.2NP_001197.1  Krueppel-like factor 9

    See identical proteins and their annotated locations for NP_001197.1

    Status: REVIEWED

    Source sequence(s)
    AI458659, AI693223, AL162390, BC069431, BE221978
    Consensus CDS
    CCDS6633.1
    UniProtKB/Swiss-Prot
    Q13886
    UniProtKB/TrEMBL
    A0A024R260
    Related
    ENSP00000366330.2, ENST00000377126.3
    Conserved Domains (2) summary
    COG5048
    Location:94234
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:145167
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    70384597..70414657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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