Gstt4 glutathione S-transferase, theta 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gstt4provided by RGD
Full Name: glutathione S-transferase, theta 4provided by RGD
Primary source: RGD:1591294
See related: Ensembl:ENSRNOG00000038300 AllianceGenome:RGD:1591294
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Orthologous to human GSTT4 (glutathione S-transferase theta 4). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward (RPKM 547.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (12834613..12841730)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (12835178..12842306)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (13778185..13784813)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione S-transferase theta-4

Names: GST class-theta-4

NP_001103145.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109675.1 → NP_001103145.1 glutathione S-transferase theta-4

See identical proteins and their annotated locations for NP_001103145.1

Status: PROVISIONAL

Source sequence(s)

CH473988

UniProtKB/Swiss-Prot

Q4V8E6

UniProtKB/TrEMBL

A6JKG7

Related

ENSRNOP00000055115.3, ENSRNOT00000058314.6

Conserved Domains (2) summary

cd03183
Location:92 → 216

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

cd03050
Location:3 → 78

GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...