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Slc44a2 solute carrier family 44, member 2 [ Mus musculus (house mouse) ]

Gene ID: 68682, updated on 12-May-2024

Summary

Official Symbol
Slc44a2provided by MGI
Official Full Name
solute carrier family 44, member 2provided by MGI
Primary source
MGI:MGI:1915932
See related
Ensembl:ENSMUSG00000057193 AllianceGenome:MGI:1915932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTL2; 1110028E10Rik
Summary
Predicted to enable choline transmembrane transporter activity. Predicted to be involved in choline transport and transmembrane transport. Predicted to be located in mitochondrion and plasma membrane. Predicted to be active in membrane. Is expressed in embryo. Orthologous to human SLC44A2 (solute carrier family 44 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 112.2), lung adult (RPKM 80.3) and 23 other tissues See more
Orthologs
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Genomic context

See Slc44a2 in Genome Data Viewer
Location:
9 A3; 9 7.77 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21232015..21266324)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21320719..21355028)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase inhibitor 2D Neighboring gene adaptor protein complex AP-1, mu 2 subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21125421-21125608 Neighboring gene predicted gene, 39302 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21132507-21132711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21136702-21136885 Neighboring gene predicted gene, 36198 Neighboring gene interleukin enhancer binding factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E2284 Neighboring gene predicted gene, 16853

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables choline transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ethanolamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in choline transport ISO
Inferred from Sequence Orthology
more info
 
involved_in ethanolamine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
choline transporter-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199186.1NP_001186115.1  choline transporter-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001186115.1

    Status: VALIDATED

    Source sequence(s)
    AK041533, BU756489, BY339157
    Consensus CDS
    CCDS90511.1
    UniProtKB/Swiss-Prot
    Q8BY89
    Related
    ENSMUSP00000150147.2, ENSMUST00000217461.2
    Conserved Domains (2) summary
    pfam04515
    Location:317673
    Choline_transpo; Plasma-membrane choline transporter
    cl01738
    Location:226322
    DUF898; Bacterial protein of unknown function (DUF898)
  2. NM_001359227.1NP_001346156.1  choline transporter-like protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122525
    Conserved Domains (2) summary
    pfam04515
    Location:318673
    Choline_transpo; Plasma-membrane choline transporter
    cl26602
    Location:245275
    SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
  3. NM_152808.3NP_690021.1  choline transporter-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_690021.1

    Status: VALIDATED

    Source sequence(s)
    AK048648, AK166695, BU756489
    Consensus CDS
    CCDS22903.1
    UniProtKB/Swiss-Prot
    Q8BY89, Q8K2F1
    Related
    ENSMUSP00000034697.8, ENSMUST00000034697.8
    Conserved Domains (2) summary
    pfam04515
    Location:319675
    Choline_transpo; Plasma-membrane choline transporter
    cl01738
    Location:228324
    DUF898; Bacterial protein of unknown function (DUF898)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    21232015..21266324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242593.3XP_011240895.1  choline transporter-like protein 2 isoform X1

    Conserved Domains (2) summary
    cl38913
    Location:258298
    ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
    pfam04515
    Location:341697
    Choline_transpo; Plasma-membrane choline transporter
  2. XM_030244550.1XP_030100410.1  choline transporter-like protein 2 isoform X2

    Conserved Domains (2) summary
    TIGR03375
    Location:268298
    type_I_sec_LssB; type I secretion system ATPase, LssB family
    pfam04515
    Location:341697
    Choline_transpo; Plasma-membrane choline transporter
  3. XM_036155232.1XP_036011125.1  choline transporter-like protein 2 isoform X1

    Conserved Domains (2) summary
    cl38913
    Location:258298
    ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
    pfam04515
    Location:341697
    Choline_transpo; Plasma-membrane choline transporter
  4. XM_006510576.3XP_006510639.1  choline transporter-like protein 2 isoform X3

    Conserved Domains (2) summary
    TIGR03375
    Location:247277
    type_I_sec_LssB; type I secretion system ATPase, LssB family
    pfam04515
    Location:320676
    Choline_transpo; Plasma-membrane choline transporter