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Trpm4 transient receptor potential cation channel, subfamily M, member 4 [ Mus musculus (house mouse) ]

Gene ID: 68667, updated on 13-May-2024

Summary

Official Symbol
Trpm4provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily M, member 4provided by MGI
Primary source
MGI:MGI:1915917
See related
Ensembl:ENSMUSG00000038260 AllianceGenome:MGI:1915917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LTRPC4; TRPM4B; LTrpC-4; 1110030C19Rik
Summary
Enables ATP binding activity; calcium activated cation channel activity; and calcium channel activity. Involved in several processes, including cellular response to ATP; dendritic cell chemotaxis; and protein homotetramerization. Acts upstream of or within calcium ion transport. Located in plasma membrane. Is spanning component of plasma membrane. Is expressed in brain; cochlea; dorsal root ganglion; inferior vagus ganglion; and vagus ganglion. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 6 and progressive familial heart block type IB. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 55.6), duodenum adult (RPKM 35.6) and 14 other tissues See more
Orthologs
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Genomic context

See Trpm4 in Genome Data Viewer
Location:
7 B3; 7 29.24 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44952579..44983495, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45303155..45334071, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 21 Neighboring gene STARR-positive B cell enhancer ABC_E6543 Neighboring gene predicted gene, 39006 Neighboring gene ribosomal protein L14, pseudogene 1 Neighboring gene histidine rich calcium binding protein Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 Neighboring gene STARR-positive B cell enhancer ABC_E2237 Neighboring gene STARR-positive B cell enhancer ABC_E700 Neighboring gene metastasis associated gene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • FLJ20041

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-activated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated monoatomic ion channel activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ATP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in inorganic cation transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during AV node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during Purkinje myocyte cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during bundle of His cell action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of adipose tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of sodium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transient receptor potential cation channel subfamily M member 4
Names
calcium-activated non-selective cation channel 1
long transient receptor potential channel 4
transient receptor potential ion channel melastatin subgroup member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175130.4NP_780339.2  transient receptor potential cation channel subfamily M member 4

    See identical proteins and their annotated locations for NP_780339.2

    Status: VALIDATED

    Source sequence(s)
    AC150897, AK044094, BB840481, BC058632, BY097409, BY304579, BY335443
    Consensus CDS
    CCDS52245.1
    UniProtKB/Swiss-Prot
    Q6PDM0, Q769E2, Q769E4, Q7TN37, Q80Y94, Q80YB3, Q811E2
    Related
    ENSMUSP00000040367.9, ENSMUST00000042194.10
    Conserved Domains (1) summary
    pfam00520
    Location:855943
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44952579..44983495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153400.1XP_036009293.1  transient receptor potential cation channel subfamily M member 4 isoform X1

  2. XM_006541146.5XP_006541209.1  transient receptor potential cation channel subfamily M member 4 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GS49
    Related
    ENSMUSP00000147793.2, ENSMUST00000211743.2
    Conserved Domains (2) summary
    pfam00520
    Location:708796
    Ion_trans; Ion transport protein
    cl39032
    Location:4199
    LSDAT_euk; SLOG in TRPM
  3. XM_030242952.2XP_030098812.1  transient receptor potential cation channel subfamily M member 4 isoform X3

    Conserved Domains (1) summary
    pfam00520
    Location:500588
    Ion_trans; Ion transport protein

RNA

  1. XR_003946552.2 RNA Sequence

  2. XR_004934179.1 RNA Sequence

  3. XR_004934180.1 RNA Sequence

  4. XR_004934178.1 RNA Sequence

  5. XR_391361.4 RNA Sequence

  6. XR_882034.3 RNA Sequence

  7. XR_882033.3 RNA Sequence

  8. XR_882035.3 RNA Sequence

  9. XR_882036.3 RNA Sequence

  10. XR_004934181.1 RNA Sequence

  11. XR_003946553.2 RNA Sequence

  12. XR_003946554.1 RNA Sequence