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TACR2 tachykinin receptor 2 [ Homo sapiens (human) ]

Gene ID: 6865, updated on 1-Jun-2020

Summary

Official Symbol
TACR2provided by HGNC
Official Full Name
tachykinin receptor 2provided by HGNC
Primary source
HGNC:HGNC:11527
See related
Ensembl:ENSG00000075073 MIM:162321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SKR; NK2R; NKNAR; TAC2R
Summary
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 8.8), endometrium (RPKM 7.3) and 9 other tissues See more
Orthologs

Genomic context

See TACR2 in Genome Data Viewer
Location:
10q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (69403903..69416918, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71163958..71176674, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928994 Neighboring gene hexokinase domain containing 1 Neighboring gene hexokinase 1 Neighboring gene ribosomal protein S15a pseudogene 28 Neighboring gene Sharpr-MPRA regulatory region 2430 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates tachykinin receptor 2 in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
substance K receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tachykinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
excretion TAS
Traceable Author Statement
more info
PubMed 
intestine smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
muscle contraction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of luteinizing hormone secretion IEA
Inferred from Electronic Annotation
more info
 
operant conditioning IEA
Inferred from Electronic Annotation
more info
 
positive regulation of acetylcholine secretion, neurotransmission IEA
Inferred from Electronic Annotation
more info
 
positive regulation of flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of uterine smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
prolactin secretion IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
tachykinin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
sperm head IDA
Inferred from Direct Assay
more info
PubMed 
sperm midpiece IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
substance-K receptor
Names
NK-2 receptor
NK-2R
neurokinin 2 receptor
neurokinin A receptor
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001057.3NP_001048.2  substance-K receptor

    See identical proteins and their annotated locations for NP_001048.2

    Status: VALIDATED

    Source sequence(s)
    AC016821, BC033742, DA929480
    Consensus CDS
    CCDS7293.1
    UniProtKB/Swiss-Prot
    P21452
    Related
    ENSP00000362403.4, ENST00000373306.5
    Conserved Domains (2) summary
    pfam00001
    Location:50307
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:42168
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    69403903..69416918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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