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Mtcl1 microtubule crosslinking factor 1 [ Mus musculus (house mouse) ]

Gene ID: 68617, updated on 31-Jan-2019

Summary

Official Symbol
Mtcl1provided by MGI
Official Full Name
microtubule crosslinking factor 1provided by MGI
Primary source
MGI:MGI:1915867
See related
Ensembl:ENSMUSG00000052105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Soga2; Ccdc165; Kiaa0802; t8219b25; mKIAA0802; D130071O13; 1110012J17Rik
Expression
Broad expression in cerebellum adult (RPKM 17.8), lung adult (RPKM 10.2) and 15 other tissues See more
Orthologs

Genomic context

See Mtcl1 in Genome Data Viewer
Location:
17; 17 E1.1
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (66336980..66449806, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (66686322..66799090, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 20742 Neighboring gene periphilin 1 pseudogene Neighboring gene predicted gene 4705 Neighboring gene RAB12, member RAS oncogene family Neighboring gene predicted gene, 41608 Neighboring gene thymocyte selection associated family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC77963

Gene Ontology Provided by MGI

Function Evidence Code Pubs
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
apicolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule bundle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule bundle IDA
Inferred from Direct Assay
more info
PubMed 
midbody IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
midbody ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
microtubule cross-linking factor 1
Names
PAR-1-interacting protein
SOGA family member 2
coiled-coil domain-containing protein 165
protein SOGA2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114098.2NP_001107570.1  microtubule cross-linking factor 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    CT010496, CT025601
    Consensus CDS
    CCDS50168.1
    UniProtKB/Swiss-Prot
    Q3UHU5
    Related
    ENSMUSP00000094894.3, ENSMUST00000097291.9
    Conserved Domains (5) summary
    pfam00261
    Location:338543
    Tropomyosin; Tropomyosin
    pfam10812
    Location:123182
    DUF2561; Protein of unknown function (DUF2561)
    pfam11365
    Location:622714
    DUF3166; Protein of unknown function (DUF3166)
    pfam13863
    Location:432533
    DUF4200; Domain of unknown function (DUF4200)
    pfam14818
    Location:12201341
    DUF4482; Domain of unknown function (DUF4482)
  2. NM_172963.4NP_766551.3  microtubule cross-linking factor 1 isoform 2

    See identical proteins and their annotated locations for NP_766551.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' region, which results in a downstream translation termination codon, compared to variant 1. The resulting isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK147205, BP760436
    Consensus CDS
    CCDS28946.2
    UniProtKB/Swiss-Prot
    Q3UHU5
    Related
    ENSMUSP00000083899.5, ENSMUST00000086693.11
    Conserved Domains (5) summary
    pfam00261
    Location:338543
    Tropomyosin; Tropomyosin
    pfam10812
    Location:123182
    DUF2561; Protein of unknown function (DUF2561)
    pfam11365
    Location:622714
    DUF3166; Protein of unknown function (DUF3166)
    pfam13863
    Location:432533
    DUF4200; Domain of unknown function (DUF4200)
    pfam14818
    Location:12201341
    DUF4482; Domain of unknown function (DUF4482)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    66336980..66449806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524849.2XP_006524912.1  microtubule cross-linking factor 1 isoform X1

    Conserved Domains (4) summary
    COG1842
    Location:340570
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam10812
    Location:123182
    DUF2561; Protein of unknown function (DUF2561)
    pfam11365
    Location:658750
    DUF3166; Protein of unknown function (DUF3166)
    pfam14818
    Location:12971418
    DUF4482; Domain of unknown function (DUF4482)
  2. XM_011246587.2XP_011244889.1  microtubule cross-linking factor 1 isoform X6

    Related
    ENSMUSP00000135690.1, ENSMUST00000177034.1
    Conserved Domains (5) summary
    pfam00261
    Location:338543
    Tropomyosin; Tropomyosin
    pfam10812
    Location:123182
    DUF2561; Protein of unknown function (DUF2561)
    pfam11365
    Location:622714
    DUF3166; Protein of unknown function (DUF3166)
    pfam13863
    Location:432533
    DUF4200; Domain of unknown function (DUF4200)
    pfam14818
    Location:12611382
    DUF4482; Domain of unknown function (DUF4482)
  3. XM_017317622.1XP_017173111.1  microtubule cross-linking factor 1 isoform X7

  4. XM_006524856.3XP_006524919.1  microtubule cross-linking factor 1 isoform X5

    Conserved Domains (4) summary
    COG1842
    Location:340570
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam10812
    Location:123182
    DUF2561; Protein of unknown function (DUF2561)
    pfam11365
    Location:658750
    DUF3166; Protein of unknown function (DUF3166)
    pfam14818
    Location:12971418
    DUF4482; Domain of unknown function (DUF4482)
  5. XM_006524852.3XP_006524915.1  microtubule cross-linking factor 1 isoform X3

    Conserved Domains (5) summary
    pfam00261
    Location:338543
    Tropomyosin; Tropomyosin
    pfam10812
    Location:123182
    DUF2561; Protein of unknown function (DUF2561)
    pfam11365
    Location:622714
    DUF3166; Protein of unknown function (DUF3166)
    pfam13863
    Location:432533
    DUF4200; Domain of unknown function (DUF4200)
    pfam14818
    Location:12611382
    DUF4482; Domain of unknown function (DUF4482)
  6. XM_006524851.3XP_006524914.1  microtubule cross-linking factor 1 isoform X2

    Conserved Domains (4) summary
    pfam10812
    Location:123182
    DUF2561; Protein of unknown function (DUF2561)
    pfam11365
    Location:633725
    DUF3166; Protein of unknown function (DUF3166)
    pfam14818
    Location:12721393
    DUF4482; Domain of unknown function (DUF4482)
    pfam14988
    Location:341544
    DUF4515; Domain of unknown function (DUF4515)
  7. XM_006524853.3XP_006524916.1  microtubule cross-linking factor 1 isoform X4

    Conserved Domains (4) summary
    COG1842
    Location:340570
    PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
    pfam10812
    Location:123182
    DUF2561; Protein of unknown function (DUF2561)
    pfam11365
    Location:658750
    DUF3166; Protein of unknown function (DUF3166)
    pfam14818
    Location:12561377
    DUF4482; Domain of unknown function (DUF4482)

RNA

  1. XR_001782108.1 RNA Sequence

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