Ppm1f protein phosphatase 1F (PP2C domain containing) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppm1fprovided by MGI
Official Full Name: protein phosphatase 1F (PP2C domain containing)provided by MGI
Primary source: MGI:MGI:1918464
See related: Ensembl:ENSMUSG00000026181 AllianceGenome:MGI:1918464
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Popx2; CaMKPase; mKIAA0015; 1110021B16Rik; 4933427B07Rik
Summary: Predicted to enable calmodulin-dependent protein phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in several processes, including positive regulation of cellular component biogenesis; protein dephosphorylation; and regulation of macromolecule metabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Ubiquitous expression in lung adult (RPKM 18.7), subcutaneous fat pad adult (RPKM 12.2) and 28 other tissues See more
Orthologs: all
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Genomic context

Location:: 16 A3; 16 10.48 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (16714314..16745239)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (16896469..16927375)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Medial prefrontal cortical PPM1F alters depression-related behaviors by modifying p300 activity via the AMPK signaling pathway.
Title: Medial prefrontal cortical PPM1F alters depression-related behaviors by modifying p300 activity via the AMPK signaling pathway.
PPM1F in Dentate Gyrus Modulates Anxiety-Related Behaviors by Regulating BDNF Expression via AKT/JNK/p-H3S10 Pathway.
Title: PPM1F in Dentate Gyrus Modulates Anxiety-Related Behaviors by Regulating BDNF Expression via AKT/JNK/p-H3S10 Pathway.
PPM1F in hippocampal dentate gyrus regulates the depression-related behaviors by modulating neuronal excitability.
Title: PPM1F in hippocampal dentate gyrus regulates the depression-related behaviors by modulating neuronal excitability.
PPM1F controls integrin activity via a conserved phospho-switch.
Title: PPM1F controls integrin activity via a conserved phospho-switch.
Ppm1f is involved in stress- and trauma-related manifestation of anxiety and depression.
Title: Expression of the PPM1F Gene Is Regulated by Stress and Associated With Anxiety and Depression.
C-terminal cytoplasmic fragment of PcdhgC5 acts as a scaffold for CaMKP and CaMKI to regulate CaMKP activity.
Title: Regulation of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) by protocadherin-γC5 (Pcdh-γC5).
The POPX2 phosphatase regulates cancer cell motility and invasiveness.
Title: The POPX2 phosphatase regulates cancer cell motility and invasiveness.
The binding of POPX2 (PPM1F) to mDia1 or to an mDia-containing complex greatly decreases the ability of mDia1 to activate transcription from the serum response element (SRE).
Title: Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237443

Ppm1f (e-PCR), detects polymorphism
- UniSTS:496034

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables calmodulin-dependent protein phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cation binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell-cell adhesion mediated by cadherin	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein phosphatase 1F

Names: ca(2+)/calmodulin-dependent protein kinase phosphatase; caM-kinase phosphatase; calcium/calmodulin-dependent protein kinase phosphatase; partner of PIX2

NP_789803.1

EC 3.1.3.16

XP_017172613.1

EC 3.1.3.16

XP_036015997.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176833.4 → NP_789803.1 protein phosphatase 1F

See identical proteins and their annotated locations for NP_789803.1

Status: VALIDATED

Source sequence(s)

AC166832, AK016942, AK164964

Consensus CDS

CCDS27991.1

UniProtKB/Swiss-Prot

Q8CGA0

Related

ENSMUSP00000027373.10, ENSMUST00000027373.12

Conserved Domains (1) summary

pfam00481
Location:152 → 403

PP2C; Protein phosphatase 2C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

16714314..16745239

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160104.1 → XP_036015997.1 protein phosphatase 1F isoform X2

Conserved Domains (1) summary

cd00143
Location:1 → 245

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_017317124.3 → XP_017172613.1 protein phosphatase 1F isoform X1

UniProtKB/Swiss-Prot

Q8CGA0

Conserved Domains (1) summary

pfam00481
Location:152 → 403

PP2C; Protein phosphatase 2C