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SYT4 synaptotagmin 4 [ Homo sapiens (human) ]

Gene ID: 6860, updated on 7-Dec-2018

Summary

Official Symbol
SYT4provided by HGNC
Official Full Name
synaptotagmin 4provided by HGNC
Primary source
HGNC:HGNC:11512
See related
Ensembl:ENSG00000132872 MIM:600103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT1192
Expression
Biased expression in brain (RPKM 34.8), adrenal (RPKM 10.3) and 1 other tissue See more
Orthologs

Genomic context

See SYT4 in Genome Data Viewer
Location:
18q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (43267892..43277650, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (40847857..40857615, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 907 Neighboring gene RNA, 5S ribosomal pseudogene 454 Neighboring gene Ras like without CAAX 2 Neighboring gene uncharacterized LOC105372088 Neighboring gene uncharacterized LOC105372087 Neighboring gene RNA, U6 small nuclear 443, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of synaptotagmin IV (SYT4) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1342

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
syntaxin-1 binding IEA
Inferred from Electronic Annotation
more info
 
syntaxin-3 binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
brain development IEA
Inferred from Electronic Annotation
more info
 
calcium ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion-dependent exocytosis NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of catecholamine secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of retrograde trans-synaptic signaling by neuropeptide IEA
Inferred from Electronic Annotation
more info
 
negative regulation of short-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vesicle fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion-dependent exocytosis NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of dendrite extension IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of presynaptic dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
 
secretory granule maturation IEA
Inferred from Electronic Annotation
more info
 
trans-synaptic signaling by BDNF, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
vesicle fusion with vesicle IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
astrocyte projection IEA
Inferred from Electronic Annotation
more info
 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
dense core granule membrane NAS
Non-traceable Author Statement
more info
PubMed 
exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of Golgi membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of neuronal dense core vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of synaptic vesicle membrane NAS
Non-traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
microvesicle IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection terminus IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
synaptotagmin-4
Names
synaptotagmin IV
sytIV

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020783.4NP_065834.1  synaptotagmin-4

    See identical proteins and their annotated locations for NP_065834.1

    Status: VALIDATED

    Source sequence(s)
    AB037763, AI912792, BC036538, BM311221, DB483932
    Consensus CDS
    CCDS11922.1
    UniProtKB/Swiss-Prot
    Q9H2B2
    Related
    ENSP00000255224.2, ENST00000255224.7
    Conserved Domains (2) summary
    cd08388
    Location:153279
    C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
    cd08404
    Location:288423
    C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    43267892..43277650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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