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Ubxn2a UBX domain protein 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 685859, updated on 3-Jun-2026
Official Symbol
Ubxn2aprovided by RGD
Official Full Name
UBX domain protein 2Aprovided by RGD
Primary source
RGD:1589027
See related
Ensembl:ENSRNOG00000068687 AllianceGenome:RGD:1589027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ubxd4
Summary
Predicted to enable acetylcholine receptor binding activity and ubiquitin binding activity. Acts upstream of or within regulation of gene expression. Predicted to be located in cis-Golgi network and endoplasmic reticulum. Predicted to be active in cytosol and nucleus. Orthologous to human UBXN2A (UBX domain protein 2A). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Muscle (RPKM 362.0), Heart (RPKM 211.1) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Ubxn2a in Genome Data Viewer
Location:
6q14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (33603804..33645958, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (27884364..27912767, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (28969471..28997987, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene WD repeat and coiled coil containing Neighboring gene MFSD2 lysolipid transporter B, sphingolipid Neighboring gene ATPase family, AAA domain containing 2B Neighboring gene uncharacterized LOC134479334 Neighboring gene kelch-like family member 29

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. Teng Y, et al. Biochem Pharmacol, 2015 Oct 15. PMID 26265139, Free PMC Article
  2. UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. Rezvani K, et al. J Neurosci, 2009 May 27. PMID 19474315, Free PMC Article
  3. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data of this study suggested that UBXD4 modulates the distribution of alpha3* nAChRs between specialized intracellular compartments and the plasma membrane.
    Title: UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylcholine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear membrane reassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus EXP
Inferred from Experiment
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum EXP
Inferred from Experiment
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
UBX domain-containing protein 2A
Names
UBX domain containing 4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109482.2 → NP_001102952.1  UBX domain-containing protein 2A

    See identical proteins and their annotated locations for NP_001102952.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    A6HAJ7, D3ZID8
    UniProtKB/TrEMBL
    A0ABK0LB12
    Related
    ENSRNOP00000076999.1, ENSRNOT00000098597.2
    Conserved Domains (2) summary
    cd17160
    Location:168 → 251
    UBX_UBXN2A; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 2A (UBXN2A) and similar proteins
    pfam08059
    Location:66 → 139
    SEP; SEP domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    33603804..33645958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262479.1 → XP_063118549.1  UBX domain-containing protein 2A isoform X1

    UniProtKB/Swiss-Prot
    A6HAJ7, D3ZID8
    UniProtKB/TrEMBL
    A0ABK0LB12

  2. XM_039112932.2 → XP_038968860.1  UBX domain-containing protein 2A isoform X2

    Conserved Domains (2) summary
    pfam08059
    Location:66 → 139
    SEP; SEP domain
    cl28922
    Location:143 → 198
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_039112930.2 → XP_038968858.1  UBX domain-containing protein 2A isoform X1

    UniProtKB/Swiss-Prot
    A6HAJ7, D3ZID8
    UniProtKB/TrEMBL
    A0ABK0LB12
    Conserved Domains (2) summary
    cd17160
    Location:168 → 251
    UBX_UBXN2A; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 2A (UBXN2A) and similar proteins
    pfam08059
    Location:66 → 139
    SEP; SEP domain

  4. XM_063262480.1 → XP_063118550.1  UBX domain-containing protein 2A isoform X3

    UniProtKB/TrEMBL
    A6HAJ9

  5. XM_039112931.2 → XP_038968859.1  UBX domain-containing protein 2A isoform X1

    UniProtKB/Swiss-Prot
    A6HAJ7, D3ZID8
    UniProtKB/TrEMBL
    A0ABK0LB12
    Related
    ENSRNOP00000107835.1, ENSRNOT00000170494.1
    Conserved Domains (2) summary
    cd17160
    Location:168 → 251
    UBX_UBXN2A; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 2A (UBXN2A) and similar proteins
    pfam08059
    Location:66 → 139
    SEP; SEP domain

  6. XM_063262477.1 → XP_063118547.1  UBX domain-containing protein 2A isoform X1

    UniProtKB/Swiss-Prot
    A6HAJ7, D3ZID8
    UniProtKB/TrEMBL
    A0ABK0LB12
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZID8.1 GenPept UniProtKB/Swiss-Prot:D3ZID8

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