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Rtn4 reticulon 4 [ Mus musculus (house mouse) ]

Gene ID: 68585, updated on 21-Apr-2024

Summary

Official Symbol
Rtn4provided by MGI
Official Full Name
reticulon 4provided by MGI
Primary source
MGI:MGI:1915835
See related
Ensembl:ENSMUSG00000020458 AllianceGenome:MGI:1915835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ASY; NgA; NOGO; NSP-CL; Nogo-A; Nogo-B; Nogo-C; mKIAA0886; mKIAA4153; 1110020G17Rik; C130026I10Rik
Summary
Predicted to enable cadherin binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including neurogenesis; positive regulation of leukocyte migration; and vasculogenesis. Acts upstream of or within blastocyst formation; circulatory system development; and regulation of cell growth. Located in several cellular components, including dendritic growth cone; neuronal cell body; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; limb mesenchyme; sensory organ; and skeletal musculature. Orthologous to human RTN4 (reticulon 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 70.4), frontal lobe adult (RPKM 55.5) and 27 other tissues See more
Orthologs
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Genomic context

Location:
11 A3.3; 11 16.79 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29642898..29694414)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29692898..29744414)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29028 Neighboring gene predicted gene 12092 Neighboring gene predicted gene, 53675 Neighboring gene STARR-positive B cell enhancer ABC_E3937 Neighboring gene STARR-seq mESC enhancer starr_29030 Neighboring gene STARR-seq mESC enhancer starr_29032 Neighboring gene STARR-seq mESC enhancer starr_29033 Neighboring gene STARR-seq mESC enhancer starr_29034 Neighboring gene STARR-positive B cell enhancer ABC_E2351 Neighboring gene STARR-seq mESC enhancer starr_29036 Neighboring gene apurinic/apyrimidinic endonuclease 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29037 Neighboring gene STARR-seq mESC enhancer starr_29038 Neighboring gene echinoderm microtubule associated protein like 6 Neighboring gene predicted gene, 39671 Neighboring gene fem-1 homolog A like Neighboring gene 60S ribosomal protein L23a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4153

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonal fasciculation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cardiac epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration involved in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in central nervous system vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebral cortex radial glia-guided migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum tubular network formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endoplasmic reticulum tubular network formation ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum tubular network membrane organization ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular sphingolipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte migration involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear pore complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERBB3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Rac protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 9 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to lysosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of branching morphogenesis of a nerve IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of branching morphogenesis of a nerve ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynapse assembly EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum tubular network membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
reticulon-4
Names
neurite outgrowth inhibitor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024226.4NP_077188.1  reticulon-4 isoform C

    See identical proteins and their annotated locations for NP_077188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different segment for its 5' end, compared to variant 1. The resulting protein (isoform C) has a shorter and distinct N-terminus when it is compared to isoform A.
    Source sequence(s)
    AK034902, BU698622, BU848611, BY251875
    Consensus CDS
    CCDS24503.1
    UniProtKB/Swiss-Prot
    Q99P72
    UniProtKB/TrEMBL
    Q78NS1
    Related
    ENSMUSP00000053754.5, ENSMUST00000060992.6
    Conserved Domains (1) summary
    pfam02453
    Location:12176
    Reticulon; Reticulon
  2. NM_194051.3NP_918940.1  reticulon-4 isoform D

    See identical proteins and their annotated locations for NP_918940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses a different segment for its 5' end, compared to variant 1. The resulting protein (isoform D) has a shorter and distinct N-terminus when it is compared to isoform A.
    Source sequence(s)
    AK034902, AL929371, BC032272, BU698622
    Consensus CDS
    CCDS24502.1
    UniProtKB/Swiss-Prot
    Q99P72
    Related
    ENSMUSP00000099905.2, ENSMUST00000102841.8
    Conserved Domains (1) summary
    pfam02453
    Location:8591023
    Reticulon; Reticulon
  3. NM_194052.3NP_918941.1  reticulon-4 isoform B1

    See identical proteins and their annotated locations for NP_918941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks one alternate exon in the coding region, compared to variant 1. The resulting protein (isoform B1) is shorter when it is compared to isoform A.
    Source sequence(s)
    AK034902, AL929371, BU698622
    Consensus CDS
    CCDS24499.1
    UniProtKB/TrEMBL
    Q8K3G7
    Related
    ENSMUSP00000077875.5, ENSMUST00000078830.11
    Conserved Domains (1) summary
    pfam02453
    Location:169333
    Reticulon; Reticulon
  4. NM_194053.3NP_918942.1  reticulon-4 isoform B2

    See identical proteins and their annotated locations for NP_918942.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the coding region, compared to variant 1. The resulting protein (isoform B2) is shorter when it is compared to isoform A.
    Source sequence(s)
    AK034902, AL929371, BU698622
    Consensus CDS
    CCDS24500.1
    UniProtKB/TrEMBL
    Q8K3G7
    Related
    ENSMUSP00000099906.4, ENSMUST00000102842.10
    Conserved Domains (1) summary
    pfam02453
    Location:188352
    Reticulon; Reticulon
  5. NM_194054.3NP_918943.1  reticulon-4 isoform A

    See identical proteins and their annotated locations for NP_918943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform A).
    Source sequence(s)
    AK034902, AL929371, BC032272, BU698622
    Consensus CDS
    CCDS24501.1
    UniProtKB/Swiss-Prot
    Q5DTK9, Q78NS1, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8BH78, Q8BHF5, Q8K290, Q8K3G8, Q99P72, Q9CTE3
    Related
    ENSMUSP00000099907.4, ENSMUST00000102843.10
    Conserved Domains (1) summary
    pfam02453
    Location:9751139
    Reticulon; Reticulon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    29642898..29694414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)