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SYPL1 synaptophysin like 1 [ Homo sapiens (human) ]

Gene ID: 6856, updated on 22-Jun-2021

Summary

Official Symbol
SYPL1provided by HGNC
Official Full Name
synaptophysin like 1provided by HGNC
Primary source
HGNC:HGNC:11507
See related
Ensembl:ENSG00000008282 MIM:616665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYPL; H-SP1
Expression
Ubiquitous expression in thyroid (RPKM 63.3), esophagus (RPKM 56.9) and 25 other tissues See more
Orthologs
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Genomic context

See SYPL1 in Genome Data Viewer
Location:
7q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (106090505..106112576, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (105730951..105753022, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cadherin related family member 3 Neighboring gene uncharacterized LOC107986833 Neighboring gene Sharpr-MPRA regulatory region 14293 Neighboring gene DDB1 and CUL4 associated factor 13 pseudogene 1 Neighboring gene RNA, U6 small nuclear 392, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46439

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
synaptophysin-like protein 1
Names
pantophysin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381910.1NP_001368839.1  synaptophysin-like protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC005095
    Conserved Domains (1) summary
    pfam01284
    Location:135257
    MARVEL; Membrane-associating domain
  2. NM_001381911.1NP_001368840.1  synaptophysin-like protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC005095
    Conserved Domains (1) summary
    pfam01284
    Location:117239
    MARVEL; Membrane-associating domain
  3. NM_001381912.1NP_001368841.1  synaptophysin-like protein 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC005095
    Conserved Domains (1) summary
    pfam01284
    Location:87209
    MARVEL; Membrane-associating domain
  4. NM_001381913.1NP_001368842.1  synaptophysin-like protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC005095
    Conserved Domains (2) summary
    pfam01284
    Location:109186
    MARVEL; Membrane-associating domain
    pfam03896
    Location:67148
    TRAP_alpha; Translocon-associated protein (TRAP), alpha subunit
  5. NM_001381915.1NP_001368844.1  synaptophysin-like protein 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC005095
    Conserved Domains (1) summary
    pfam01284
    Location:24102
    MARVEL; Membrane-associating domain
  6. NM_001381916.1NP_001368845.1  synaptophysin-like protein 1 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC005095
  7. NM_001381917.1NP_001368846.1  synaptophysin-like protein 1 isoform i precursor

    Status: VALIDATED

    Source sequence(s)
    AC005095
    Conserved Domains (1) summary
    pfam01284
    Location:181
    MARVEL; Membrane-associating domain
  8. NM_001381918.1NP_001368847.1  synaptophysin-like protein 1 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform j.
    Source sequence(s)
    AC005095
  9. NM_001381919.1NP_001368848.1  synaptophysin-like protein 1 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform j.
    Source sequence(s)
    AC005095
  10. NM_001381920.1NP_001368849.1  synaptophysin-like protein 1 isoform k

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 13, encodes isoform k.
    Source sequence(s)
    AC005095
    Conserved Domains (1) summary
    pfam01284
    Location:91185
    MARVEL; Membrane-associating domain
  11. NM_001381921.1NP_001368850.1  synaptophysin-like protein 1 isoform k

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 12, encodes isoform k.
    Source sequence(s)
    AC005095
    Related
    ENSP00000419070.1, ENST00000470347.1
    Conserved Domains (1) summary
    pfam01284
    Location:91185
    MARVEL; Membrane-associating domain
  12. NM_006754.5NP_006745.1  synaptophysin-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_006745.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC005095
    Consensus CDS
    CCDS5736.1
    UniProtKB/Swiss-Prot
    Q16563
    UniProtKB/TrEMBL
    A4D0R1
    Related
    ENSP00000011473.2, ENST00000011473.6
    Conserved Domains (1) summary
    pfam01284
    Location:109231
    MARVEL; Membrane-associating domain
  13. NM_182715.4NP_874384.1  synaptophysin-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_874384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC005095
    Consensus CDS
    CCDS47685.1
    UniProtKB/Swiss-Prot
    Q16563
    Related
    ENSP00000388336.2, ENST00000455385.7
    Conserved Domains (1) summary
    pfam01284
    Location:86213
    MARVEL; Membrane-associating domain

RNA

  1. NR_167729.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005095
  2. NR_167730.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005095

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    106090505..106112576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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