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Ecscr endothelial cell surface expressed chemotaxis and apoptosis regulator [ Mus musculus (house mouse) ]

Gene ID: 68545, updated on 23-May-2018

Summary

Official Symbol
Ecscrprovided by MGI
Official Full Name
endothelial cell surface expressed chemotaxis and apoptosis regulatorprovided by MGI
Primary source
MGI:MGI:1915795
See related
Ensembl:ENSMUSG00000073599 Vega:OTTMUSG00000033150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARIA; 1110006O17Rik
Expression
Broad expression in lung adult (RPKM 33.2), bladder adult (RPKM 20.7) and 22 other tissues See more
Orthologs

Genomic context

See Ecscr in Genome Data Viewer
Location:
18; 18 B2
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (35713086..35722725, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (35872743..35881145, complement)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 24 Neighboring gene DnaJ heat shock protein family (Hsp40) member C18 Neighboring gene RIKEN cDNA 1700066B19 gene Neighboring gene transmembrane protein 173

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of endothelial cell apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
endothelial cell-specific chemotaxis regulator
Names
apoptosis regulator through modulating IAP expression
endothelial cell-specific molecule 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033141.1NP_001028313.1  endothelial cell-specific chemotaxis regulator

    See identical proteins and their annotated locations for NP_001028313.1

    Status: PROVISIONAL

    Source sequence(s)
    AK157485
    Consensus CDS
    CCDS37763.1
    UniProtKB/Swiss-Prot
    Q3TZW0
    Related
    ENSMUSP00000095223.3, OTTMUSP00000044487, ENSMUST00000097618.9, OTTMUST00000082905
    Conserved Domains (1) summary
    pfam15820
    Location:134228
    ECSCR; Endothelial cell-specific chemotaxis regulator

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    35713086..35722725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526210.2XP_006526273.2  endothelial cell-specific chemotaxis regulator isoform X1

    Conserved Domains (1) summary
    pfam15820
    Location:204298
    ECSCR; Endothelial cell-specific chemotaxis regulator
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