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Ptx4 pentraxin 4 [ Mus musculus (house mouse) ]

Gene ID: 68509, updated on 9-Dec-2024

Summary

Official Symbol
Ptx4provided by MGI
Official Full Name
pentraxin 4provided by MGI
Primary source
MGI:MGI:1915759
See related
Ensembl:ENSMUSG00000044172 AllianceGenome:MGI:1915759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110018H23Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be located in extracellular region. Orthologous to human PTX4 (pentraxin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Ptx4 in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25339328..25344256)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25120697..25125293)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 140 Neighboring gene transmembrane protein 204 Neighboring gene telomere maintenance 2 Neighboring gene chloride channel, voltage-sensitive 7 Neighboring gene microRNA 12188 Neighboring gene coiled-coil domain containing 154 Neighboring gene proline and glutamate rich with coiled coil 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pentraxin-4
Names
neuronal pentraxin-like protein C16orf38 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163416.1NP_001156888.1  pentraxin-4 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC130711
    Consensus CDS
    CCDS89017.1
    UniProtKB/Swiss-Prot
    Q08EL0, Q148B7, Q14BG6, Q6RUU0, Q9D1A3
    UniProtKB/TrEMBL
    A0A3B2WCG1
    Related
    ENSMUSP00000156495.2, ENSMUST00000232902.2
    Conserved Domains (1) summary
    cl22861
    Location:241438
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  2. NM_026747.1NP_081023.1  pentraxin-4 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC130711
    Consensus CDS
    CCDS50031.1
    UniProtKB/Swiss-Prot
    Q08EL0, Q148B7, Q14BG6, Q6RUU0, Q9D1A3
    UniProtKB/TrEMBL
    E9QNW3
    Related
    ENSMUSP00000055984.7, ENSMUST00000054930.7
    Conserved Domains (1) summary
    cl22861
    Location:271468
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25339328..25344256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524845.4XP_006524908.1  pentraxin-4 isoform X1

    UniProtKB/Swiss-Prot
    Q08EL0, Q148B7, Q14BG6, Q6RUU0, Q9D1A3
    Conserved Domains (1) summary
    cl22861
    Location:183380
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...