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Ndufaf4 NADH:ubiquinone oxidoreductase complex assembly factor 4 [ Mus musculus (house mouse) ]

Gene ID: 68493, updated on 5-Mar-2024

Summary

Official Symbol
Ndufaf4provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase complex assembly factor 4provided by MGI
Primary source
MGI:MGI:1915743
See related
Ensembl:ENSMUSG00000028261 AllianceGenome:MGI:1915743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110007M04Rik; 3000003G13Rik
Summary
Predicted to enable calmodulin binding activity. Acts upstream of or within NADH dehydrogenase complex assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; liver lobe; lung; pectoral girdle and thoracic body wall musculature; and vibrissa. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 15. Orthologous to human NDUFAF4 (NADH:ubiquinone oxidoreductase complex assembly factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 4.0), CNS E11.5 (RPKM 3.9) and 28 other tissues See more
Orthologs
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Genomic context

See Ndufaf4 in Genome Data Viewer
Location:
4 A3; 4 10.52 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (24898083..24905001)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (24898083..24905001)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene kelch-like 32 Neighboring gene predicted gene, 31436 Neighboring gene STARR-seq mESC enhancer starr_09783 Neighboring gene predicted gene, 31379 Neighboring gene predicted gene, 46848 Neighboring gene RIKEN cDNA C230012O17 gene Neighboring gene G protein-coupled receptor 63 Neighboring gene four and a half LIM domains 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4
hormone-regulated proliferation-associated protein of 20 kDa homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026742.4NP_081018.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

    See identical proteins and their annotated locations for NP_081018.1

    Status: VALIDATED

    Source sequence(s)
    AK160341, AL772223, BY163651
    Consensus CDS
    CCDS18007.1
    UniProtKB/Swiss-Prot
    Q3TV72, Q9D1H6
    Related
    ENSMUSP00000029925.4, ENSMUST00000029925.10
    Conserved Domains (1) summary
    pfam06784
    Location:1165
    UPF0240; uncharacterized protein family (UPF0240)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    24898083..24905001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)