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Adipor2 adiponectin receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 68465, updated on 19-Mar-2019

Summary

Official Symbol
Adipor2provided by MGI
Official Full Name
adiponectin receptor 2provided by MGI
Primary source
MGI:MGI:93830
See related
Ensembl:ENSMUSG00000030168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADCR2; Paqr2; AI115388; AW554121; D6Ucla1e; 1110001I14Rik
Expression
Ubiquitous expression in mammary gland adult (RPKM 96.4), liver adult (RPKM 91.0) and 28 other tissues See more
Orthologs

Genomic context

See Adipor2 in Genome Data Viewer
Location:
6 F1; 6 56.78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (119353150..119417483, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (119303168..119367501, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1C subunit Neighboring gene decapping mRNA 1B Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4 Neighboring gene leucine-rich repeats and transmembrane domains 2 Neighboring gene wingless-type MMTV integration site family, member 5B Neighboring gene predicted gene, 40397 Neighboring gene F-box and leucine-rich repeat protein 14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
    AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Leptin and adiponectin, organism-specific biosystem (from WikiPathways)
    Leptin and adiponectin, organism-specific biosystemProposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
adipokinetic hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
adiponectin binding IPI
Inferred from Physical Interaction
more info
PubMed 
adiponectin binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adiponectin-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adiponectin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adiponectin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adiponectin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
vascular wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adiponectin receptor protein 2
Names
progestin and adipoQ receptor family member 2
progestin and adipoQ receptor family member II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355692.1NP_001342621.1  adiponectin receptor protein 2

    Status: VALIDATED

    Source sequence(s)
    AC115816, AC126607
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related
  2. NM_197985.4NP_932102.2  adiponectin receptor protein 2

    See identical proteins and their annotated locations for NP_932102.2

    Status: VALIDATED

    Source sequence(s)
    AC115816, AC126607
    Consensus CDS
    CCDS20473.1
    UniProtKB/Swiss-Prot
    Q8BQS5
    UniProtKB/TrEMBL
    Q53YY3
    Related
    ENSMUSP00000032272.6, ENSMUST00000032272.12
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    119353150..119417483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506538.2XP_006506601.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BQS5
    UniProtKB/TrEMBL
    Q53YY3
    Related
    ENSMUSP00000126138.1, ENSMUST00000169744.7
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related
  2. XM_011241448.2XP_011239750.1  adiponectin receptor protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011239750.1

    UniProtKB/Swiss-Prot
    Q8BQS5
    UniProtKB/TrEMBL
    Q53YY3
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related
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