Adipor2 adiponectin receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adipor2provided by MGI
Official Full Name: adiponectin receptor 2provided by MGI
Primary source: MGI:MGI:93830
See related: Ensembl:ENSMUSG00000030168 AllianceGenome:MGI:93830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADCR2; Paqr2; D6Ucla1e; 1110001I14Rik
Summary: Enables adiponectin binding activity; identical protein binding activity; and signaling receptor activity. Involved in glucose homeostasis; positive regulation of cold-induced thermogenesis; and vascular wound healing. Acts upstream of or within adiponectin-activated signaling pathway. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease and type 2 diabetes mellitus. Orthologous to human ADIPOR2 (adiponectin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in mammary gland adult (RPKM 96.4), liver adult (RPKM 91.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 56.78 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (119330111..119394489, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (119353150..119417699, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation.
Title: The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation.
ADIPOR activation restores AMPK (AMP-activated protein kinase)-mediated autophagosome formation and antioxidant-mediated autophagosome clearance, representing a novel intervention effective against myocardial ischemia-reperfusion injury in diabetic conditions.
Title: Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling.
these results demonstrate that AdipoR1 and AdipoR2 exhibit overlapping and distinct effects in skeletal muscle consistent with enhanced adiponectin sensitivity but these appear insufficient to ameliorate established obesity-induced adiponectin resistance.
Title: Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects.
macrophage polarization is a key determinant regulating AdipoR expression and differential APN-mediated macrophage inflammatory responses
Title: Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response.
AdipoR1, but not AdipoR2 deficiency, leads to diet-induced metabolic dysfunction, revealing that these receptors have highly divergent roles in vascular and metabolic homeostasis
Title: Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo.
Data suggest GnRH (gonadotropin-releasing hormone) neurons in forebrain express AdipoR2 (not AdipoR1); adiponectin/AdipoR2 signal transduction via protein kinase C zeta down-regulates neurotransmission in subpopulation of GnRH neurons.
Title: Metabolic influences on reproduction: adiponectin attenuates GnRH neuronal activity in female mice.
These results prove that elevation of adiponectin and/or adipoR2 expression via gene transfer is an effective approach in managing obesity epidemics.
Title: Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-induced obesity and insulin resistance.
APN, AdipoR1, and AdipoR2 exist in human and mouse retinas and retinal APN and AdipoR1 protein levels are elevated in type 1 diabetes mellitus mice.
Title: Expression of adiponectin and its receptors in type 1 diabetes mellitus in human and mouse retinas.
Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue.
Title: Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice.
Human biosynthetic insulin had little or no effect in the regulation of AdipoR1 expression in 3T3-L1 cells, but significantly up-regulated AdipoR2 mRNA level in a biphasic manner.
Title: Insulin-regulated expression of adiponectin receptors in muscle and fat cells.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adipor2 (e-PCR), detects polymorphism
- UniSTS:471067

AW554121 (e-PCR)
- UniSTS:185682

Adipor2 (e-PCR), detects polymorphism
- UniSTS:496004

Homology

Homologs of the Adipor2 gene: The Adipor2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, mosquito, A.thaliana, and rice.
Orthologs from Annotation Pipeline: 347 organisms have orthologs with human gene Adipor2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables adiponectin binding	IPI Inferred from Physical Interaction more info	PubMed
enables adiponectin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within adiponectin-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adiponectin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hepatic stellate cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in vascular wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adiponectin receptor protein 2

Names: progestin and adipoQ receptor family member 2; progestin and adipoQ receptor family member II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355692.1 → NP_001342621.1 adiponectin receptor protein 2

Status: VALIDATED

Source sequence(s)

AC115816, AC126607

Consensus CDS

CCDS20473.1

UniProtKB/Swiss-Prot

Q8CID6

UniProtKB/TrEMBL

Q53YY3

Related

ENSMUSP00000126138.2, ENSMUST00000169744.8

Conserved Domains (1) summary

pfam03006
Location:140 → 363

HlyIII; Haemolysin-III related
NM_197985.4 → NP_932102.2 adiponectin receptor protein 2

See identical proteins and their annotated locations for NP_932102.2

Status: VALIDATED

Source sequence(s)

AC115816, AC126607

Consensus CDS

CCDS20473.1

UniProtKB/Swiss-Prot

Q8BQS5, Q8CID6

UniProtKB/TrEMBL

Q53YY3

Related

ENSMUSP00000032272.7, ENSMUST00000032272.13

Conserved Domains (1) summary

pfam03006
Location:140 → 363

HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

119330111..119394489 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255576.2 → XP_030111436.1 adiponectin receptor protein 2 isoform X2

Conserved Domains (1) summary

pfam03006
Location:65 → 288

HlyIII; Haemolysin-III related
XM_030255574.1 → XP_030111434.1 adiponectin receptor protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8CID6

UniProtKB/TrEMBL

Q53YY3

Conserved Domains (1) summary

pfam03006
Location:140 → 363

HlyIII; Haemolysin-III related