Adipor2 adiponectin receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adipor2provided by MGI
Official Full Name: adiponectin receptor 2provided by MGI
Primary source: MGI:MGI:93830
See related: Ensembl:ENSMUSG00000030168
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADCR2; Paqr2; AI115388; AW554121; D6Ucla1e; 1110001I14Rik
Expression: Ubiquitous expression in mammary gland adult (RPKM 96.4), liver adult (RPKM 91.0) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 6 F1; 6 56.78 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	6	NC_000072.6 (119353150..119417483, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	6	NC_000072.5 (119303168..119367501, complement)

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

these results demonstrate that AdipoR1 and AdipoR2 exhibit overlapping and distinct effects in skeletal muscle consistent with enhanced adiponectin sensitivity but these appear insufficient to ameliorate established obesity-induced adiponectin resistance.
Title: Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects.
macrophage polarization is a key determinant regulating AdipoR expression and differential APN-mediated macrophage inflammatory responses
Title: Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response.
AdipoR1, but not AdipoR2 deficiency, leads to diet-induced metabolic dysfunction, revealing that these receptors have highly divergent roles in vascular and metabolic homeostasis
Title: Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo.
Data suggest GnRH (gonadotropin-releasing hormone) neurons in forebrain express AdipoR2 (not AdipoR1); adiponectin/AdipoR2 signal transduction via protein kinase C zeta down-regulates neurotransmission in subpopulation of GnRH neurons.
Title: Metabolic influences on reproduction: adiponectin attenuates GnRH neuronal activity in female mice.
These results prove that elevation of adiponectin and/or adipoR2 expression via gene transfer is an effective approach in managing obesity epidemics.
Title: Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-induced obesity and insulin resistance.
APN, AdipoR1, and AdipoR2 exist in human and mouse retinas and retinal APN and AdipoR1 protein levels are elevated in type 1 diabetes mellitus mice.
Title: Expression of adiponectin and its receptors in type 1 diabetes mellitus in human and mouse retinas.
Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue.
Title: Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice.
Human biosynthetic insulin had little or no effect in the regulation of AdipoR1 expression in 3T3-L1 cells, but significantly up-regulated AdipoR2 mRNA level in a biphasic manner.
Title: Insulin-regulated expression of adiponectin receptors in muscle and fat cells.
Gene expression of adiponectin and AdipoR1/AdipoR2 receptors gradually increases during the wound healing process.
Title: Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway.
The messenger RNA expression levels of hepatic adiponectin receptor (AdipoR)-1 and AdipoR2 and skeletal muscular AdipoR1 were up-regulated by tiliroside treatment.
Title: Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation

Pathways from BioSystems

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AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
AMPK signaling pathway, organism-specific biosystem (from KEGG)
AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
AMPK signaling pathway, conserved biosystem (from KEGG)
AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Adipocytokine signaling pathway, conserved biosystem (from KEGG)
Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Integration of energy metabolism, organism-specific biosystem (from REACTOME)
Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Leptin and adiponectin, organism-specific biosystem (from WikiPathways)
Leptin and adiponectin, organism-specific biosystemProposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].
Longevity regulating pathway, organism-specific biosystem (from KEGG)
Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...

General gene information

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Markers

Adipor2 (e-PCR), detects polymorphism
- UniSTS:471067

AW554121 (e-PCR)
- UniSTS:185682

Adipor2 (e-PCR), detects polymorphism
- UniSTS:496004

Homology

Homologs of the Adipor2 gene: The Adipor2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, mosquito, A.thaliana, and rice.
Orthologs from Annotation Pipeline: 236 organisms have orthologs with human gene Adipor2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
adiponectin binding	IPI Inferred from Physical Interaction more info	PubMed
adiponectin binding	ISO Inferred from Sequence Orthology more info
identical protein binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
adiponectin-activated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
adiponectin-activated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
adiponectin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
lipid metabolic process	IEA Inferred from Electronic Annotation more info
negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of glucose import	ISO Inferred from Sequence Orthology more info
vascular wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
integral component of membrane	IEA Inferred from Electronic Annotation more info
intrinsic component of plasma membrane	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adiponectin receptor protein 2

Names: progestin and adipoQ receptor family member 2; progestin and adipoQ receptor family member II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355692.1 → NP_001342621.1 adiponectin receptor protein 2

Status: VALIDATED

Source sequence(s)

AC115816, AC126607

Conserved Domains (1) summary

pfam03006
Location:140 → 363

HlyIII; Haemolysin-III related
NM_197985.4 → NP_932102.2 adiponectin receptor protein 2

See identical proteins and their annotated locations for NP_932102.2

Status: VALIDATED

Source sequence(s)

AC115816, AC126607

Consensus CDS

CCDS20473.1

UniProtKB/Swiss-Prot

Q8BQS5

UniProtKB/TrEMBL

Q53YY3

Related

ENSMUSP00000032272.6, ENSMUST00000032272.12

Conserved Domains (1) summary

pfam03006
Location:140 → 363

HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38.p4 C57BL/6J

Range

119353150..119417483 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506538.2 → XP_006506601.1 adiponectin receptor protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8BQS5

UniProtKB/TrEMBL

Q53YY3

Related

ENSMUSP00000126138.1, ENSMUST00000169744.7

Conserved Domains (1) summary

pfam03006
Location:140 → 363

HlyIII; Haemolysin-III related
XM_011241448.2 → XP_011239750.1 adiponectin receptor protein 2 isoform X1

See identical proteins and their annotated locations for XP_011239750.1

UniProtKB/Swiss-Prot

Q8BQS5

UniProtKB/TrEMBL

Q53YY3

Conserved Domains (1) summary

pfam03006
Location:140 → 363

HlyIII; Haemolysin-III related