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Adipor2 adiponectin receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 68465, updated on 8-Feb-2024

Summary

Official Symbol
Adipor2provided by MGI
Official Full Name
adiponectin receptor 2provided by MGI
Primary source
MGI:MGI:93830
See related
Ensembl:ENSMUSG00000030168 AllianceGenome:MGI:93830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADCR2; Paqr2; D6Ucla1e; 1110001I14Rik
Summary
Enables adiponectin binding activity; identical protein binding activity; and signaling receptor activity. Involved in glucose homeostasis; positive regulation of cold-induced thermogenesis; and vascular wound healing. Acts upstream of or within adiponectin-activated signaling pathway. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease and type 2 diabetes mellitus. Orthologous to human ADIPOR2 (adiponectin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 96.4), liver adult (RPKM 91.0) and 28 other tissues See more
Orthologs
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Genomic context

See Adipor2 in Genome Data Viewer
Location:
6 F1; 6 56.78 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119330111..119394489, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119353150..119417699, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4 Neighboring gene predicted gene, 52874 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119286263-119286553 Neighboring gene leucine-rich repeats and transmembrane domains 2 Neighboring gene STARR-positive B cell enhancer ABC_E9099 Neighboring gene STARR-seq mESC enhancer starr_17147 Neighboring gene STARR-seq mESC enhancer starr_17149 Neighboring gene wingless-type MMTV integration site family, member 5B Neighboring gene predicted gene, 40397 Neighboring gene F-box and leucine-rich repeat protein 14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adipokinetic hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables adiponectin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables adiponectin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adiponectin-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adiponectin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adiponectin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adiponectin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hepatic stellate cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adiponectin receptor protein 2
Names
progestin and adipoQ receptor family member 2
progestin and adipoQ receptor family member II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355692.1NP_001342621.1  adiponectin receptor protein 2

    Status: VALIDATED

    Source sequence(s)
    AC115816, AC126607
    Consensus CDS
    CCDS20473.1
    UniProtKB/Swiss-Prot
    Q8BQS5, Q8CA45, Q8CID6
    UniProtKB/TrEMBL
    Q53YY3
    Related
    ENSMUSP00000126138.2, ENSMUST00000169744.8
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related
  2. NM_197985.4NP_932102.2  adiponectin receptor protein 2

    See identical proteins and their annotated locations for NP_932102.2

    Status: VALIDATED

    Source sequence(s)
    AC115816, AC126607
    Consensus CDS
    CCDS20473.1
    UniProtKB/Swiss-Prot
    Q8BQS5, Q8CA45, Q8CID6
    UniProtKB/TrEMBL
    Q53YY3
    Related
    ENSMUSP00000032272.7, ENSMUST00000032272.13
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    119330111..119394489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255576.2XP_030111436.1  adiponectin receptor protein 2 isoform X2

    Conserved Domains (1) summary
    pfam03006
    Location:65288
    HlyIII; Haemolysin-III related
  2. XM_030255574.1XP_030111434.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BQS5, Q8CA45, Q8CID6
    UniProtKB/TrEMBL
    Q53YY3
    Conserved Domains (1) summary
    pfam03006
    Location:140363
    HlyIII; Haemolysin-III related

RNA

  1. XR_004933620.1 RNA Sequence