Tbc1d10b TBC1 domain family, member 10b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbc1d10bprovided by MGI
Official Full Name: TBC1 domain family, member 10bprovided by MGI
Primary source: MGI:MGI:1915699
See related: Ensembl:ENSMUSG00000042492 AllianceGenome:MGI:1915699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110003P22Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and retrograde transport, endosome to Golgi. Predicted to be located in plasma membrane. Orthologous to human TBC1D10B (TBC1 domain family member 10B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 22.9), ovary adult (RPKM 16.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.38 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126796631..126807640, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127197459..127208468, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EPI64B can serve as a potential physiological GAP for Rab27B and thereby participate in the regulation of exocytosis in pancreatic acinar cells.
Title: EPI64B acts as a GTPase-activating protein for Rab27B in pancreatic acinar cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TBC1 domain family member 10B

Names: protein wz3-85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144522.5 → NP_653105.3 TBC1 domain family member 10B

See identical proteins and their annotated locations for NP_653105.3

Status: VALIDATED

Source sequence(s)

AC122537, AK047320

Consensus CDS

CCDS40139.2

UniProtKB/Swiss-Prot

Q6GQW9, Q6PIZ5, Q8BHL3, Q91XR3

Related

ENSMUSP00000113307.2, ENSMUST00000120705.3

Conserved Domains (2) summary

smart00164
Location:343 → 548

TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

PRK12323
Location:37 → 227

PRK12323; DNA polymerase III subunit gamma/tau