Rcor3 REST corepressor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rcor3provided by RGD
Full Name: REST corepressor 3provided by RGD
Primary source: RGD:1593864
See related: Ensembl:ENSRNOG00000046445 AllianceGenome:RGD:1593864
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Orthologous to human RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Heart (RPKM 61.0), Lung (RPKM 55.9) and 9 other tissues See more
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Location:: 13q27

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (106156166..106196542, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (103624966..103665565, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (110822149..110864469, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH142341 (e-PCR)
- UniSTS:231588

BI288530 (e-PCR)
- UniSTS:246251

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: REST corepressor 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134985.1 → NP_001128457.1 REST corepressor 3

See identical proteins and their annotated locations for NP_001128457.1

Status: PROVISIONAL

Source sequence(s)

BC169033

UniProtKB/TrEMBL

A0A8I5YCF9, B5DFE7, M0R4M7

Related

ENSRNOP00000077639.2, ENSRNOT00000117569.2

Conserved Domains (4) summary

smart00717
Location:345 → 390

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:345 → 388

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:57 → 108

ELM2; ELM2 domain

cl21498
Location:144 → 188

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

106156166..106196542 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091094.2 → XP_038947022.1 REST corepressor 3 isoform X1

UniProtKB/TrEMBL

A0A8I5YCF9, A0A8I5ZS59

Related

ENSRNOP00000080003.1, ENSRNOT00000102506.2

Conserved Domains (2) summary

pfam01448
Location:57 → 108

ELM2; ELM2 domain

cl21498
Location:144 → 188

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_039091095.2 → XP_038947023.1 REST corepressor 3 isoform X2

UniProtKB/TrEMBL

A0A8I6AB49

Related

ENSRNOP00000089815.2, ENSRNOT00000110034.2

Conserved Domains (2) summary

pfam01448
Location:57 → 108

ELM2; ELM2 domain

cl21498
Location:144 → 188

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_039091096.2 → XP_038947024.1 REST corepressor 3 isoform X3

Conserved Domains (2) summary

pfam00249
Location:226 → 269

Myb_DNA-binding; Myb-like DNA-binding domain

cl21498
Location:25 → 69

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_039091098.2 → XP_038947026.1 REST corepressor 3 isoform X4

UniProtKB/TrEMBL

A0ABZ3NNP6

Related

ENSRNOP00000064314.3, ENSRNOT00000073588.4

Conserved Domains (2) summary

pfam01448
Location:57 → 108

ELM2; ELM2 domain

cl21498
Location:144 → 188

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...