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Asap3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 684122, updated on 13-Apr-2024

Summary

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Official Symbol
Asap3provided by RGD
Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3provided by RGD
Primary source
RGD:1593929
See related
Ensembl:ENSRNOG00000049714 AllianceGenome:RGD:1593929
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in cell migration; positive regulation of GTPase activity; and regulation of stress fiber assembly. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in focal adhesion; intracellular membrane-bounded organelle; and ruffle. Orthologous to human ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 56.8), Liver (RPKM 52.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153716988..153757787)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148433382..148476027)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154551901..154596125)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene inhibitor of DNA binding 3 Neighboring gene uncharacterized LOC134479041 Neighboring gene E2F transcription factor 2 Neighboring gene uncharacterized LOC134487016 Neighboring gene transcription elongation factor A3 Neighboring gene immunoglobulin heavy chain 6 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Upregulation of ASAP3 contributes to colorectal carcinogenesis and indicates poor survival outcome. Tian H, et al. Cancer Sci, 2017 Aug. PMID 28502111, Free PMC Article
  2. ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. Ha VL, et al. J Biol Chem, 2008 May 30. PMID 18400762, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427661.1 → NP_001414590.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    M0R5J1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    153716988..153757787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111294.2 → XP_038967222.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A6ITA3
    Conserved Domains (5) summary
    cd07640
    Location:21 → 221
    BAR_ASAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3
    cd13251
    Location:272 → 378
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:528 → 561
    ANK; ANK repeat [structural motif]
    cd17900
    Location:401 → 521
    ArfGap_ASAP3; ArfGAP domain of ASAP3 (ArfGAP with ANK repeat and PH domain-containing protein 3)
    pfam12796
    Location:567 → 652
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_039111295.2 → XP_038967223.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X2

    Conserved Domains (4) summary
    cd13251
    Location:21 → 127
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:277 → 310
    ANK; ANK repeat [structural motif]
    cd17900
    Location:150 → 270
    ArfGap_ASAP3; ArfGAP domain of ASAP3 (ArfGAP with ANK repeat and PH domain-containing protein 3)
    pfam12796
    Location:316 → 401
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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