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MED22 mediator complex subunit 22 [ Homo sapiens (human) ]

Gene ID: 6837, updated on 17-Jun-2019

Summary

Official Symbol
MED22provided by HGNC
Official Full Name
mediator complex subunit 22provided by HGNC
Primary source
HGNC:HGNC:11477
See related
Ensembl:ENSG00000148297 MIM:185641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRB6; MED24; SURF5; surf-5
Summary
This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in ovary (RPKM 8.5), thyroid (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See MED22 in Genome Data Viewer
Location:
9q34.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (133338312..133348156, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136207751..136215011, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene lipocalin 1 pseudogene 2 Neighboring gene surfeit 6 Neighboring gene ribosomal protein L21 pseudogene 81 Neighboring gene Sharpr-MPRA regulatory region 11826 Neighboring gene ribosomal protein L7a Neighboring gene small nucleolar RNA, C/D box 24 Neighboring gene small nucleolar RNA, C/D box 36B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.
NHGRI GWA Catalog

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SURF6

Homology

Clone Names

  • MGC48682

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 22
Names
surfeit locus protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133640.5NP_598395.1  mediator of RNA polymerase II transcription subunit 22 isoform b

    See identical proteins and their annotated locations for NP_598395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) represents the shorter transcript and encodes the longer isoform (b).
    Source sequence(s)
    AJ224359, AL772161, GD160955, HY154869
    Consensus CDS
    CCDS6963.1
    UniProtKB/Swiss-Prot
    Q15528
    UniProtKB/TrEMBL
    A0A024R8C5
    Related
    ENSP00000342343.5, ENST00000343730.9
    Conserved Domains (1) summary
    pfam06179
    Location:20124
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex
  2. NM_181491.2NP_852468.1  mediator of RNA polymerase II transcription subunit 22 isoform c

    See identical proteins and their annotated locations for NP_852468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) differs in the 3' UTR and its transcription extends past a splice site used in variant b, resulting in a distinct 3' coding region. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AL772161, BC024225, GD160955, HY154869
    Consensus CDS
    CCDS6964.1
    UniProtKB/Swiss-Prot
    Q15528
    Related
    ENSP00000478773.1, ENST00000610888.4
    Conserved Domains (1) summary
    pfam06179
    Location:20124
    Med22; Surfeit locus protein 5 subunit 22 of Mediator complex

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    133338312..133348156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646201.1 Reference GRCh38.p13 PATCHES

    Range
    164406..174250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_006752.4: Suppressed sequence

    Description
    NM_006752.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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