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Sirt5 sirtuin 5 [ Mus musculus (house mouse) ]

Gene ID: 68346, updated on 9-Dec-2024

Summary

Official Symbol
Sirt5provided by MGI
Official Full Name
sirtuin 5provided by MGI
Primary source
MGI:MGI:1915596
See related
Ensembl:ENSMUSG00000054021 AllianceGenome:MGI:1915596
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610012J09Rik; 1500032M05Rik
Summary
Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in protein deacylation and regulation of ketone biosynthetic process. Acts upstream of or within regulation of succinate dehydrogenase activity and response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; heart; oocyte; palatal shelf; and sensory organ. Orthologous to human SIRT5 (sirtuin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in heart adult (RPKM 3.8), bladder adult (RPKM 2.9) and 28 other tissues See more
Orthologs
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Genomic context

See Sirt5 in Genome Data Viewer
Location:
13 A4; 13 21.6 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (43518849..43549073)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (43365389..43395203)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52047 Neighboring gene predicted gene, 53796 Neighboring gene RAN binding protein 9 Neighboring gene nucleolar protein 7 Neighboring gene predicted gene, 26064

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent protein lysine deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase activity, NAD-dependent IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-glutaryllysine deglutarylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-glutaryllysine deglutarylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-glutaryllysine deglutarylase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-malonyllysine demalonylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-malonyllysine demalonylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-malonyllysine demalonylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-malonyllysine demalonylase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-succinyllysine desuccinylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-succinyllysine desuccinylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-succinyllysine desuccinylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-succinyllysine desuccinylase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-lysine demalonylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine demalonylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-lysine desuccinylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine desuccinylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine desuccinylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in protein deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein deglutarylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deglutarylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein demalonylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein demalonylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein desuccinylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein desuccinylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein desuccinylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ketone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of succinate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Names
NAD-dependent deacetylase sirtuin-5
NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
NP_849179.1
XP_006517014.1
XP_006517015.1
XP_006517016.1
XP_006517017.1
XP_011242714.1
XP_011242715.1
XP_030103247.1
XP_030103248.1
XP_030103249.1
XP_030103250.1
XP_036014035.1
XP_036014036.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178848.3NP_849179.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial

    See identical proteins and their annotated locations for NP_849179.1

    Status: PROVISIONAL

    Source sequence(s)
    AC132121
    Consensus CDS
    CCDS26478.1
    UniProtKB/Swiss-Prot
    Q8K2C6
    UniProtKB/TrEMBL
    A0A1Y7VJY8
    Related
    ENSMUSP00000152796.2, ENSMUST00000223194.2
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    43518849..43549073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516951.3XP_006517014.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517014.1

    UniProtKB/TrEMBL
    A0A1Y7VJY8, A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  2. XM_006516954.2XP_006517017.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00195
    Location:4181
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  3. XM_036158143.1XP_036014036.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl00195
    Location:4179
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  4. XM_030247387.2XP_030103247.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8K2C6
    UniProtKB/TrEMBL
    A0A1Y7VJY8
    Related
    ENSMUSP00000152740.2, ENSMUST00000220576.2
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  5. XM_036158142.1XP_036014035.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00195
    Location:4181
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  6. XM_006516953.3XP_006517016.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517016.1

    UniProtKB/TrEMBL
    A0A1Y7VJY8, A0A1Y7VM56
    Related
    ENSMUSP00000152526.2, ENSMUST00000221515.2
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  7. XM_006516952.5XP_006517015.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517015.1

    UniProtKB/TrEMBL
    A0A1Y7VJY8, A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  8. XM_030247390.2XP_030103250.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl00195
    Location:4179
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  9. XM_030247388.2XP_030103248.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8K2C6
    UniProtKB/TrEMBL
    A0A1Y7VJY8
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  10. XM_011244413.3XP_011242715.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242715.1

    UniProtKB/TrEMBL
    A0A1Y7VJY8, A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  11. XM_030247389.2XP_030103249.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8K2C6
    UniProtKB/TrEMBL
    A0A1Y7VJY8
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  12. XM_011244412.3XP_011242714.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242714.1

    UniProtKB/TrEMBL
    A0A1Y7VJY8, A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...