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Sirt5 sirtuin 5 [ Mus musculus (house mouse) ]

Gene ID: 68346, updated on 16-Jun-2018

Summary

Official Symbol
Sirt5provided by MGI
Official Full Name
sirtuin 5provided by MGI
Primary source
MGI:MGI:1915596
See related
Ensembl:ENSMUSG00000054021
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AV001953; 0610012J09Rik; 1500032M05Rik
Expression
Ubiquitous expression in heart adult (RPKM 3.8), bladder adult (RPKM 2.9) and 28 other tissues See more
Orthologs

Genomic context

See Sirt5 in Genome Data Viewer
Location:
13; 13 A4
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (43365439..43395203)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (43460904..43490572)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40929 Neighboring gene glucose-fructose oxidoreductase domain containing 1 Neighboring gene RAN binding protein 9 Neighboring gene nucleolar protein 7 Neighboring gene predicted gene, 32878

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD+ binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-glutaryllysine deglutarylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-glutaryllysine deglutarylase activity ISO
Inferred from Sequence Orthology
more info
 
protein-malonyllysine demalonylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-malonyllysine demalonylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-malonyllysine demalonylase activity ISO
Inferred from Sequence Orthology
more info
 
protein-succinyllysine desuccinylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-succinyllysine desuccinylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-succinyllysine desuccinylase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
peptidyl-lysine demalonylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine demalonylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-lysine desuccinylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine desuccinylation ISO
Inferred from Sequence Orthology
more info
 
protein deglutarylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deglutarylation ISO
Inferred from Sequence Orthology
more info
 
protein demalonylation IDA
Inferred from Direct Assay
more info
PubMed 
protein demalonylation ISO
Inferred from Sequence Orthology
more info
 
protein desuccinylation IDA
Inferred from Direct Assay
more info
PubMed 
protein desuccinylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein desuccinylation ISO
Inferred from Sequence Orthology
more info
 
regulation of ketone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Names
NAD-dependent deacetylase sirtuin-5
NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
NP_849179.1
XP_006517014.1
XP_006517015.1
XP_006517016.1
XP_006517017.1
XP_011242714.1
XP_011242715.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178848.3NP_849179.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial

    See identical proteins and their annotated locations for NP_849179.1

    Status: PROVISIONAL

    Source sequence(s)
    AC132121
    Consensus CDS
    CCDS26478.1
    UniProtKB/Swiss-Prot
    Q8K2C6
    Related
    ENSMUSP00000152796.1, ENSMUST00000223194.1
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    43365439..43395203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516951.1XP_006517014.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517014.1

    UniProtKB/TrEMBL
    A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  2. XM_006516952.3XP_006517015.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517015.1

    UniProtKB/TrEMBL
    A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  3. XM_006516953.1XP_006517016.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517016.1

    UniProtKB/TrEMBL
    A0A1Y7VM56
    Related
    ENSMUSP00000152526.1, ENSMUST00000221515.1
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  4. XM_011244413.2XP_011242715.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242715.1

    UniProtKB/TrEMBL
    A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  5. XM_011244412.1XP_011242714.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242714.1

    UniProtKB/TrEMBL
    A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...
  6. XM_006516954.1XP_006517017.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00195
    Location:4181
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
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