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Prss52 protease, serine 52 [ Rattus norvegicus (Norway rat) ]

Gene ID: 683422, updated on 29-Feb-2024

Summary

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Official Symbol
Prss52provided by RGD
Official Full Name
protease, serine 52provided by RGD
Primary source
RGD:1586868
See related
Ensembl:ENSRNOG00000047632 AllianceGenome:RGD:1586868
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 49.9), Brain (RPKM 15.3) and 3 other tissues See more
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Genomic context

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Location:
15p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (42520384..42529218)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (38344486..38353316)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (47465648..47475294)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene serine protease 55 Neighboring gene serine protease 51 Neighboring gene uncharacterized LOC120097017 Neighboring gene methionine sulfoxide reductase A Neighboring gene large ribosomal subunit protein eL37-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine protease 52

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    42520384..42529218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252191.5 → XP_006252253.1  serine protease 52 isoform X1

    See identical proteins and their annotated locations for XP_006252253.1

    UniProtKB/TrEMBL
    A6K6H4, M0RDW0
    Related
    ENSRNOP00000067823.3
    Conserved Domains (2) summary
    smart00020
    Location:46 → 272
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:46 → 275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_008770796.4 → XP_008769018.1  serine protease 52 isoform X2

    See identical proteins and their annotated locations for XP_008769018.1

    Conserved Domains (1) summary
    cd00190
    Location:2 → 229
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_039093925.2 → XP_038949853.1  serine protease 52 isoform X3

    Conserved Domains (1) summary
    cl21584
    Location:46 → 173
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version

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