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Rab13 RAB13, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 68328, updated on 8-Dec-2022

Summary

Official Symbol
Rab13provided by MGI
Official Full Name
RAB13, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1927232
See related
Ensembl:ENSMUSG00000027935 AllianceGenome:MGI:1927232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610007N03Rik; B230212B15Rik
Summary
Predicted to enable GTP binding activity and protein kinase A catalytic subunit binding activity. Involved in endocytic recycling; endothelial cell chemotaxis; and protein localization to cell leading edge. Located in several cellular components, including bicellular tight junction; endocytic vesicle; and lamellipodium. Is expressed in brain; early conceptus; lung; meninges; and secondary oocyte. Orthologous to human RAB13 (RAB13, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.2), limb E14.5 (RPKM 5.9) and 27 other tissues See more
Orthologs
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Genomic context

See Rab13 in Genome Data Viewer
Location:
3 F1; 3 39.21 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90121022..90133694)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90213715..90226387)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 210-like Neighboring gene predicted gene, 24185 Neighboring gene ribosomal protein S27 Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene jumping translocation breakpoint Neighboring gene solute carrier family 39 (zinc transporter), member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Golgi vesicle fusion to target membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cortical actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of Sertoli cell barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell leading edge IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in insulin-responsive compartment ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
is_active_in trans-Golgi network transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293741.1NP_001280670.1  ras-related protein Rab-13 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the use of an alternate promoter, has a different 5' structure, and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC119825, AI529508, AK080805
    Consensus CDS
    CCDS79962.1
    UniProtKB/TrEMBL
    D3YUS4
    Related
    ENSMUSP00000102996.2, ENSMUST00000107373.8
    Conserved Domains (1) summary
    cl21455
    Location:191
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_026677.4NP_080953.1  ras-related protein Rab-13 isoform 1

    See identical proteins and their annotated locations for NP_080953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC119825, AI529508, AK002303, AK080805, BB867138
    Consensus CDS
    CCDS17522.1
    UniProtKB/Swiss-Prot
    Q9DD03
    Related
    ENSMUSP00000070588.7, ENSMUST00000065418.7
    Conserved Domains (2) summary
    smart00175
    Location:9170
    RAB; Rab subfamily of small GTPases
    cd01867
    Location:6172
    Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90121022..90133694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)