Tnfaip3 TNF alpha induced protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnfaip3provided by RGD
Official Full Name: TNF alpha induced protein 3provided by RGD
Primary source: RGD:1589275
See related: Ensembl:ENSRNOG00000049517 AllianceGenome:RGD:1589275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; deubiquitinase activity; and enzyme binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; negative regulation of signal transduction; and protein modification by small protein conjugation or removal. Predicted to act upstream of or within several processes, including negative regulation of interleukin-1 beta production; positive regulation of protein catabolic process; and protein K63-linked deubiquitination. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; esophageal cancer; and familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Thymus (RPKM 140.9), Spleen (RPKM 109.6) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 1p12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (15528921..15543993, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (13709211..13724291, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
Title: Protective effect of TNFAIP3 on testosterone production in Leydig cells under an aging inflammatory microenvironment.
TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
Title: TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.
These findings provide evidence for an adaptive role of A20 against pulmonary artery Endothelial cell angiogenesis via nuclear factor-kappa B activation.
Title: A20 deficiency leads to angiogenesis of pulmonary artery endothelial cells through stronger NF-κB activation under hypoxia.
Clematichinenoside alleviated cerebral inflammatory injury through A20-nucleus nuclear factor kappa B signal pathway, offering an alternative medication for stroke associated with systemic inflammatory diseases.
Title: Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20.
Structure of A20-like zinc finger (A20 Znf) ubiquitin (Ub)-binding domain of Ub receptor ZNF216 shows Ub centered on Asp58, acting as a scaffold to mediate multiprotein complex assembly.
Title: Independent interactions of ubiquitin-binding domains in a ubiquitin-mediated ternary complex.
A20 downregulates adhesion markers, chemokine production, and adventitial angiogenesis, all of which are required for macrophage trafficking to sites of vascular injury
Title: A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables K63-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B-1 B cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in B-1 B cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxygen-containing compound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of protein localization to vacuole	ISO Inferred from Sequence Orthology more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD40 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chronic inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chronic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 5 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of toll-like receptor 5 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K11-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of germinal center formation	IEA Inferred from Electronic Annotation more info
involved_in regulation of germinal center formation	ISO Inferred from Sequence Orthology more info
involved_in response to molecule of bacterial origin	IEA Inferred from Electronic Annotation more info
involved_in response to molecule of bacterial origin	ISO Inferred from Sequence Orthology more info
involved_in response to muramyl dipeptide	IEA Inferred from Electronic Annotation more info
involved_in response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
involved_in tolerance induction to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in tolerance induction to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor alpha-induced protein 3

Names: tumor necrosis factor, alpha-induced protein 3

NP_001414035.1

EC 3.4.19.12

XP_038954753.1

EC 3.4.19.12

XP_038954761.1

EC 3.4.19.12

XP_038954771.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427106.1 → NP_001414035.1 tumor necrosis factor alpha-induced protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

M0R7V5

Related

ENSRNOP00000065542.2, ENSRNOT00000074583.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

15528921..15543993 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098843.2 → XP_038954771.1 tumor necrosis factor alpha-induced protein 3 isoform X2

UniProtKB/TrEMBL

M0R7V5

Conserved Domains (2) summary

smart00259
Location:746 → 771

ZnF_A20; A20-like zinc fingers

pfam02338
Location:98 → 257

OTU; OTU-like cysteine protease
XM_039098833.2 → XP_038954761.1 tumor necrosis factor alpha-induced protein 3 isoform X2

UniProtKB/TrEMBL

M0R7V5

Conserved Domains (2) summary

smart00259
Location:746 → 771

ZnF_A20; A20-like zinc fingers

pfam02338
Location:98 → 257

OTU; OTU-like cysteine protease
XM_039098825.2 → XP_038954753.1 tumor necrosis factor alpha-induced protein 3 isoform X1

Conserved Domains (2) summary

smart00259
Location:783 → 808

ZnF_A20; A20-like zinc fingers

pfam02338
Location:135 → 294

OTU; OTU-like cysteine protease