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Rlig1 RNA 5'-phosphate and 3'-OH ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 68281, updated on 12-Apr-2023

Summary

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Official Symbol
Rlig1provided by MGI
Official Full Name
RNA 5'-phosphate and 3'-OH ligase 1provided by MGI
Primary source
MGI:MGI:1921197
See related
Ensembl:ENSMUSG00000046567 AllianceGenome:MGI:1921197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930430F08Rik; 4930571E09Rik; A730088G13Rik; C430008C19Rik
Summary
Acts upstream of or within hematopoietic progenitor cell differentiation. Is expressed in liver lobe; nervous system; and thymus primordium. Orthologous to human C12orf29 (chromosome 12 open reading frame 29). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 4.0), testis adult (RPKM 3.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Rlig1 in Genome Data Viewer
Location:
10; 10 D1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (100408136..100425252, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (100572274..100589390, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene THO complex 4 pseudogene Neighboring gene transmembrane and tetratricopeptide repeat containing 3 Neighboring gene centrosomal protein 290 Neighboring gene RIKEN cDNA 1700017N19 gene Neighboring gene predicted gene, 35722

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA ligase (ATP) activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein adenylylation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein C12orf29 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175128.2 → NP_780337.2  uncharacterized protein C12orf29 homolog

    See identical proteins and their annotated locations for NP_780337.2

    Status: VALIDATED

    Source sequence(s)
    AK160693, BC082587, CJ178338
    Consensus CDS
    CCDS24151.1
    UniProtKB/Swiss-Prot
    Q8BHN7, Q8BHV9
    Related
    ENSMUSP00000062410.9, ENSMUST00000054471.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    100408136..100425252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514028.5 → XP_006514091.1  uncharacterized protein C12orf29 homolog isoform X3

    Conserved Domains (1) summary
    pfam17720
    Location:1 → 264
    DUF5565; Family of unknown function (DUF5565)

  2. XM_036155971.1 → XP_036011864.1  uncharacterized protein C12orf29 homolog isoform X1

    Conserved Domains (1) summary
    pfam17720
    Location:1 → 346
    DUF5565; Family of unknown function (DUF5565)

  3. XM_036155972.1 → XP_036011865.1  uncharacterized protein C12orf29 homolog isoform X2

    Conserved Domains (1) summary
    pfam17720
    Location:1 → 284
    DUF5565; Family of unknown function (DUF5565)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHN7.1 GenPept UniProtKB/Swiss-Prot:Q8BHN7

Gene LinkOut

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