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Toe1 target of EGR1, member 1 (nuclear) [ Mus musculus (house mouse) ]

Gene ID: 68276, updated on 5-Jan-2023

Summary

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Official Symbol
Toe1provided by MGI
Official Full Name
target of EGR1, member 1 (nuclear)provided by MGI
Primary source
MGI:MGI:1915526
See related
Ensembl:ENSMUSG00000028688 AllianceGenome:MGI:1915526
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930584N22Rik; 4933424D16Rik
Summary
Predicted to enable poly(A)-specific ribonuclease activity and snRNA binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic and snRNA 3'-end processing. Predicted to be located in nuclear body. Predicted to be active in Cajal body and cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 7. Orthologous to human TOE1 (target of EGR1, exonuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 18.1), testis adult (RPKM 11.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Toe1 in Genome Data Viewer
Location:
4; 4 D1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116661200..116664787, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116804003..116807601, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AV051173 Neighboring gene peroxiredoxin 1 Neighboring gene methylmalonic aciduria cblC type, with homocystinuria Neighboring gene coiled-coil domain containing 163 Neighboring gene testis-specific kinase 2 Neighboring gene mutY DNA glycosylase Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockdown of Toe1 causes developmental arrest during the morula-to-blastocyst transition in mice. Wang H, et al. Theriogenology, 2022 Dec. PMID 36257135
  2. Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Lardelli RM, et al. Nat Genet, 2017 Mar. PMID 28092684, Free PMC Article
  3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of Toe1 causes developmental arrest during the morula-to-blastocyst transition in mice.
    Title: Knockdown of Toe1 causes developmental arrest during the morula-to-blastocyst transition in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables snRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, exonucleolytic ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in snRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
target of EGR1 protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026654.2 → NP_080930.1  target of EGR1 protein 1

    See identical proteins and their annotated locations for NP_080930.1

    Status: PROVISIONAL

    Source sequence(s)
    AL683847
    Consensus CDS
    CCDS18517.1
    UniProtKB/Swiss-Prot
    Q9D2E2, Q9D412
    Related
    ENSMUSP00000030451.4, ENSMUST00000030451.10
    Conserved Domains (1) summary
    pfam04857
    Location:41 → 257
    CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116661200..116664787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503353.5 → XP_006503416.1  target of EGR1 protein 1 isoform X1

    Conserved Domains (1) summary
    cl23804
    Location:1 → 39
    CAF1; CAF1 family ribonuclease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2E2.1 GenPept UniProtKB/Swiss-Prot:Q9D2E2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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