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Toporsl topoisomerase I binding, arginine/serine-rich like [ Mus musculus (house mouse) ]

Gene ID: 68274, updated on 26-Sep-2022

Summary

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Official Symbol
Toporslprovided by MGI
Official Full Name
topoisomerase I binding, arginine/serine-rich likeprovided by MGI
Primary source
MGI:MGI:1915524
See related
Ensembl:ENSMUSG00000028314 AllianceGenome:MGI:1915524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930547C10Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein monoubiquitination and protein polyubiquitination. Is expressed in ductus deferens; epididymis; esophagus; and testis. Orthologous to human TOPORSLP (topoisomerase I binding, arginine and serine rich like, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 15.4) See more
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Genomic context

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See Toporsl in Genome Data Viewer
Location:
4; 4 B2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (52596274..52612430)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (52596274..52612430)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Tmc4 retrotransposed pseudogene Neighboring gene structural maintenance of chromosomes 2 Neighboring gene VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene Neighboring gene predicted gene, 33435 Neighboring gene RIKEN cDNA 4930552N02 gene Neighboring gene nascent polypeptide-associated complex alpha polypeptide pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
topoisomerase I binding, arginine/serine-rich like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356293.1 → NP_001343222.1  topoisomerase I binding, arginine/serine-rich like

    Status: VALIDATED

    Source sequence(s)
    AK019748, AL732512, AL772233, AV041323, AV275899, BY715289
    Consensus CDS
    CCDS18182.1
    UniProtKB/TrEMBL
    Q9D2F8
    Related
    ENSMUSP00000103298.2, ENSMUST00000107671.2
    Conserved Domains (1) summary
    pfam15090
    Location:357 → 514
    DUF4553; Domain of unknown function (DUF4553)

  2. NM_026652.3 → NP_080928.1  topoisomerase I binding, arginine/serine-rich like

    See identical proteins and their annotated locations for NP_080928.1

    Status: VALIDATED

    Source sequence(s)
    AK019748, AL772233, AV041323, AV275899
    Consensus CDS
    CCDS18182.1
    UniProtKB/TrEMBL
    Q9D2F8
    Related
    ENSMUSP00000029995.6, ENSMUST00000029995.6
    Conserved Domains (1) summary
    pfam15090
    Location:357 → 514
    DUF4553; Domain of unknown function (DUF4553)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    52596274..52612430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538218.3 → XP_006538281.1  topoisomerase I binding, arginine/serine-rich like isoform X1

    See identical proteins and their annotated locations for XP_006538281.1

    UniProtKB/TrEMBL
    Q9D2F8
    Conserved Domains (1) summary
    pfam15090
    Location:357 → 514
    DUF4553; Domain of unknown function (DUF4553)

  2. XM_006538219.3 → XP_006538282.1  topoisomerase I binding, arginine/serine-rich like isoform X1

    See identical proteins and their annotated locations for XP_006538282.1

    UniProtKB/TrEMBL
    Q9D2F8
    Conserved Domains (1) summary
    pfam15090
    Location:357 → 514
    DUF4553; Domain of unknown function (DUF4553)
Nucleotide Protein Strain
Heading Accession and Version

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