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Ciao2a cytosolic iron-sulfur assembly component 2A [ Mus musculus (house mouse) ]

Gene ID: 68250, updated on 25-Apr-2023

Summary

Official Symbol
Ciao2aprovided by MGI
Official Full Name
cytosolic iron-sulfur assembly component 2Aprovided by MGI
Primary source
MGI:MGI:1915500
See related
Ensembl:ENSMUSG00000032381 AllianceGenome:MGI:1915500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam96a; 5730536A07Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to act upstream of or within chromosome segregation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of CIA complex. Is expressed in liver. Orthologous to human CIAO2A (cytosolic iron-sulfur assembly component 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 28.8), liver E14.5 (RPKM 23.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ciao2a in Genome Data Viewer
Location:
9; 9 C
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66033878..66046250)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66126596..66138968)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase B Neighboring gene sorting nexin 22 Neighboring gene sorting nexin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65972521-65972708 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65974328-65974632 Neighboring gene death-associated protein kinase 2 Neighboring gene ribosomal protein S27 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in iron-sulfur cluster assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein maturation by [4Fe-4S] cluster transfer IEA
Inferred from Electronic Annotation
more info
 
involved_in protein maturation by iron-sulfur cluster transfer ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CIA complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytosolic iron-sulfur assembly component 2A
Names
MIP18 family protein FAM96A
family with sequence similarity 96, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359210.1NP_001346139.1  cytosolic iron-sulfur assembly component 2A isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112676, AC124439
    Conserved Domains (1) summary
    cl00941
    Location:3996
    DUF59; Domain of unknown function DUF59
  2. NM_026635.3NP_080911.1  cytosolic iron-sulfur assembly component 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_080911.1

    Status: VALIDATED

    Source sequence(s)
    AK077700, BE655498
    Consensus CDS
    CCDS23302.1
    UniProtKB/Swiss-Prot
    Q9D171, Q9DCL2
    UniProtKB/TrEMBL
    A0A6P5Q4D1
    Related
    ENSMUSP00000034945.6, ENSMUST00000034945.6
    Conserved Domains (1) summary
    cl00941
    Location:39156
    FeS_assembly_P; Iron-sulfur cluster assembly protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    66033878..66046250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242805.2XP_011241107.1  cytosolic iron-sulfur assembly component 2A isoform X2

    Conserved Domains (1) summary
    cl00941
    Location:39124
    FeS_assembly_P; Iron-sulfur cluster assembly protein
  2. XM_036155224.1XP_036011117.1  cytosolic iron-sulfur assembly component 2A isoform X1

    Conserved Domains (1) summary
    cl00941
    Location:81142
    FeS_assembly_P; Iron-sulfur cluster assembly protein