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Tmbim4 transmembrane BAX inhibitor motif containing 4 [ Mus musculus (house mouse) ]

Gene ID: 68212, updated on 16-Apr-2024

Summary

Official Symbol
Tmbim4provided by MGI
Official Full Name
transmembrane BAX inhibitor motif containing 4provided by MGI
Primary source
MGI:MGI:1915462
See related
Ensembl:ENSMUSG00000020225 AllianceGenome:MGI:1915462
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610007H07Rik
Summary
Predicted to be involved in negative regulation of apoptotic process and regulation of calcium-mediated signaling. Predicted to act upstream of or within apoptotic process. Predicted to be located in Golgi stack. Orthologous to human TMBIM4 (transmembrane BAX inhibitor motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 273.2), genital fat pad adult (RPKM 142.9) and 28 other tissues See more
Orthologs
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Genomic context

See Tmbim4 in Genome Data Viewer
Location:
10 D2; 10 67.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (120044731..120060802)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (120208826..120224897)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene interleukin-1 receptor-associated kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E9354 Neighboring gene STARR-positive B cell enhancer ABC_E8371 Neighboring gene STARR-positive B cell enhancer ABC_E8372 Neighboring gene predicted gene, 40781 Neighboring gene predicted gene, 38500 Neighboring gene STARR-positive B cell enhancer ABC_E5193 Neighboring gene STARR-positive B cell enhancer ABC_E8373 Neighboring gene STARR-seq mESC enhancer starr_28059 Neighboring gene predicted gene, 40782 Neighboring gene STARR-positive B cell enhancer ABC_E3923 Neighboring gene LLP homolog, long-term synaptic facilitation (Aplysia) Neighboring gene STARR-seq mESC enhancer starr_28060 Neighboring gene STARR-seq mESC enhancer starr_28061 Neighboring gene RIKEN cDNA 1700006J14 gene Neighboring gene predicted gene, 40783 Neighboring gene high mobility group AT-hook 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein lifeguard 4
Names
Z-protein
transmembrane BAX inhibitor motif-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026617.3NP_080893.1  protein lifeguard 4

    See identical proteins and their annotated locations for NP_080893.1

    Status: PROVISIONAL

    Source sequence(s)
    AC144942
    Consensus CDS
    CCDS24205.1
    UniProtKB/Swiss-Prot
    Q9DA39
    Related
    ENSMUSP00000020446.5, ENSMUST00000020446.11
    Conserved Domains (1) summary
    cd10429
    Location:8236
    GAAP_like; Golgi antiapoptotic protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    120044731..120060802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)