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SUOX sulfite oxidase [ Homo sapiens (human) ]

Gene ID: 6821, updated on 21-Jan-2020

Summary

Official Symbol
SUOXprovided by HGNC
Official Full Name
sulfite oxidaseprovided by HGNC
Primary source
HGNC:HGNC:11460
See related
Ensembl:ENSG00000139531 MIM:606887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 16.6), liver (RPKM 11.2) and 24 other tissues See more
Orthologs

Genomic context

See SUOX in Genome Data Viewer
Location:
12q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (55992547..56005525)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56391043..56399309)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 Neighboring gene RAB13, member RAS oncogene family pseudogene Neighboring gene RAB5B, member RAS oncogene family Neighboring gene uncharacterized LOC105369781 Neighboring gene IKAROS family zinc finger 4 Neighboring gene uncharacterized LOC105369780 Neighboring gene ribosomal protein S26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Sulfite oxidase deficiency Compare labs

NHGRI GWAS Catalog

Description
A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study.
NHGRI GWA Catalog
Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
NHGRI GWA Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molybdenum ion binding IEA
Inferred from Electronic Annotation
more info
 
molybdopterin cofactor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sulfite oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
nitrate assimilation IEA
Inferred from Electronic Annotation
more info
 
sulfide oxidation, using sulfide:quinone oxidoreductase TAS
Traceable Author Statement
more info
 
sulfur compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sulfite oxidase, mitochondrial
NP_000447.2
NP_001027558.1
NP_001027559.1
XP_016875394.1
XP_016875395.1
XP_016875396.1
XP_016875397.1
XP_024304935.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008136.1 RefSeqGene

    Range
    5018..13267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000456.3NP_000447.2  sulfite oxidase, mitochondrial

    See identical proteins and their annotated locations for NP_000447.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC034102, AU126450, BC065193
    Consensus CDS
    CCDS8901.2
    UniProtKB/Swiss-Prot
    P51687
    UniProtKB/TrEMBL
    A0A024RB79
    Related
    ENSP00000377674.2, ENST00000394115.6
    Conserved Domains (2) summary
    cd02111
    Location:185543
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:86160
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
  2. NM_001032386.2NP_001027558.1  sulfite oxidase, mitochondrial

    See identical proteins and their annotated locations for NP_001027558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1.
    Source sequence(s)
    AC034102, AU121557, AU126450, BC065193
    Consensus CDS
    CCDS8901.2
    UniProtKB/Swiss-Prot
    P51687
    UniProtKB/TrEMBL
    A0A024RB79
    Related
    ENSP00000266971.3, ENST00000266971.8
    Conserved Domains (2) summary
    cd02111
    Location:185543
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:86160
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
  3. NM_001032387.2NP_001027559.1  sulfite oxidase, mitochondrial

    See identical proteins and their annotated locations for NP_001027559.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1.
    Source sequence(s)
    AC034102, AU126450, BC065193
    Consensus CDS
    CCDS8901.2
    UniProtKB/Swiss-Prot
    P51687
    UniProtKB/TrEMBL
    A0A024RB79
    Related
    ENSP00000348440.4, ENST00000356124.8
    Conserved Domains (2) summary
    cd02111
    Location:185543
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:86160
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    55992547..56005525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019907.2XP_016875396.1  sulfite oxidase, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    P51687
    UniProtKB/TrEMBL
    A0A024RB79
    Conserved Domains (2) summary
    cd02111
    Location:185543
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:86160
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
  2. XM_017019905.2XP_016875394.1  sulfite oxidase, mitochondrial isoform X1

    Conserved Domains (2) summary
    cd02111
    Location:192550
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:93167
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
  3. XM_024449167.1XP_024304935.1  sulfite oxidase, mitochondrial isoform X1

    Conserved Domains (2) summary
    cd02111
    Location:192550
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:93167
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
  4. XM_017019908.1XP_016875397.1  sulfite oxidase, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    P51687
    UniProtKB/TrEMBL
    A0A024RB79
    Conserved Domains (2) summary
    cd02111
    Location:185543
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:86160
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
  5. XM_017019906.1XP_016875395.1  sulfite oxidase, mitochondrial isoform X1

    Conserved Domains (2) summary
    cd02111
    Location:192550
    eukary_SO_Moco; molybdopterin binding domain of sulfite oxidase (SO). SO catalyzes the terminal reaction in the oxidative degradation of the sulfur-containing amino acids cysteine and methionine. Common features of all known members of the sulfite oxidase (SO) family of ...
    pfam00173
    Location:93167
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
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