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BSG basigin (Ok blood group) [ Homo sapiens (human) ]

Gene ID: 682, updated on 24-Nov-2020

Summary

Official Symbol
BSGprovided by HGNC
Official Full Name
basigin (Ok blood group)provided by HGNC
Primary source
HGNC:HGNC:1116
See related
Ensembl:ENSG00000172270 MIM:109480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OK; 5F7; TCSF; CD147; EMPRIN; HAb18G; EMMPRIN; SLC7A11
Summary
The protein encoded by this gene, basigin, is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Basigin is also a member of the immunoglobulin superfamily, ubiquitously expressed in various tissues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
Expression
Ubiquitous expression in heart (RPKM 230.6), colon (RPKM 194.1) and 25 other tissues See more
Orthologs

Genomic context

See BSG in Genome Data Viewer
Location:
19p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (571283..583493)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (571277..583493)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene granzyme M Neighboring gene CRISPRi-validated cis-regulatory element chr19.73 Neighboring gene BSG antisense RNA 1 Neighboring gene Rho GTPase activating protein 33 pseudogene Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Neighboring gene uncharacterized LOC107987266

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env The functional interaction between CD98 and CD147 is involved in the regulation of HIV-1 gp160-mediated cell fusion PubMed
Tat tat Application of HIV-1 Tat transmembrane transport peptide to cells induces PKN1 gene and slightly represses two genes, ZCD1 and BSG PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannose binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
decidualization IEA
Inferred from Electronic Annotation
more info
 
dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
pyruvate metabolic process TAS
Traceable Author Statement
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to mercury ion IEA
Inferred from Electronic Annotation
more info
 
response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 
plasma membrane HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
basigin
Names
OK blood group antigen
collagenase stimulatory factor
extracellular matrix metalloproteinase inducer
hepatoma-associated antigen
leukocyte activation antigen M6
tumor cell-derived collagenase stimulatory factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007468.1 RefSeqGene

    Range
    6272..17169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322243.2NP_001309172.1  basigin isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC009005, CB153773, GU557064
    Consensus CDS
    CCDS12034.1
    UniProtKB/Swiss-Prot
    P35613
    UniProtKB/TrEMBL
    Q54A51
    Conserved Domains (1) summary
    smart00410
    Location:112202
    IG_like; Immunoglobulin like
  2. NM_001728.4NP_001719.2  basigin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001719.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AY358113, GU557064
    Consensus CDS
    CCDS12033.1
    UniProtKB/Swiss-Prot
    P35613
    Related
    ENSP00000333769.3, ENST00000333511.9
    Conserved Domains (3) summary
    cd00096
    Location:40114
    Ig; Immunoglobulin domain
    smart00410
    Location:228318
    IG_like; Immunoglobulin like
    cl11960
    Location:219317
    Ig; Immunoglobulin domain
  3. NM_198589.3NP_940991.1  basigin isoform 2 precursor

    See identical proteins and their annotated locations for NP_940991.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 5 both encode the same isoform (2).
    Source sequence(s)
    AB085790, GU557064
    Consensus CDS
    CCDS12034.1
    UniProtKB/Swiss-Prot
    P35613
    UniProtKB/TrEMBL
    Q54A51
    Related
    ENSP00000343809.4, ENST00000353555.8
    Conserved Domains (1) summary
    smart00410
    Location:112202
    IG_like; Immunoglobulin like
  4. NM_198590.3NP_940992.1  basigin isoform 3

    See identical proteins and their annotated locations for NP_940992.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    DA007913, GU557064
    Consensus CDS
    CCDS58635.1
    UniProtKB/Swiss-Prot
    P35613
    Related
    ENSP00000473664.1, ENST00000545507.6
    Conserved Domains (2) summary
    smart00410
    Location:19109
    IG_like; Immunoglobulin like
    cl11960
    Location:10108
    Ig; Immunoglobulin domain
  5. NM_198591.4NP_940993.2  basigin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC009005, GU557065
    Consensus CDS
    CCDS12032.1
    Related
    ENSP00000344707.3, ENST00000346916.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    571283..583493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027173.2XP_016882662.1  basigin isoform X1

    UniProtKB/Swiss-Prot
    P35613
    Conserved Domains (3) summary
    cd00096
    Location:40114
    Ig; Immunoglobulin domain
    smart00410
    Location:228318
    IG_like; Immunoglobulin like
    cl11960
    Location:219317
    Ig; Immunoglobulin domain
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