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SULT1C2 sulfotransferase family 1C member 2 [ Homo sapiens (human) ]

Gene ID: 6819, updated on 8-Jul-2021

Summary

Official Symbol
SULT1C2provided by HGNC
Official Full Name
sulfotransferase family 1C member 2provided by HGNC
Primary source
HGNC:HGNC:11456
See related
Ensembl:ENSG00000198203 MIM:602385
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST1C1; ST1C2; SULT1C1; humSULTC2
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 61.8), kidney (RPKM 26.2) and 3 other tissues See more
Orthologs
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Genomic context

See SULT1C2 in Genome Data Viewer
Location:
2q12.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (108288895..108309915)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (108905351..108926371)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1C member 3 Neighboring gene WASF1 pseudogene 1 Neighboring gene sulfotransferase family, cytosolic, 1C, member 2 pseudogene 2 Neighboring gene sulfotransferase family 1C member 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in amine metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within sulfation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sulfation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfotransferase 1C2
Names
SULT1C#1
sulfotransferase 1C1
sulfotransferase family, cytosolic, 1C, member 1
sulfotransferase family, cytosolic, 1C, member 2
NP_001047.1
NP_789795.1
XP_005264070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001056.4NP_001047.1  sulfotransferase 1C2 isoform a

    See identical proteins and their annotated locations for NP_001047.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and it encodes isoform a.
    Source sequence(s)
    AA856596, AC019100, AF186252
    Consensus CDS
    CCDS2075.1
    UniProtKB/Swiss-Prot
    O00338
    Related
    ENSP00000251481.6, ENST00000251481.11
    Conserved Domains (1) summary
    pfam00685
    Location:39288
    Sulfotransfer_1; Sulfotransferase domain
  2. NM_176825.3NP_789795.1  sulfotransferase 1C2 isoform b

    See identical proteins and their annotated locations for NP_789795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains one alternate in-frame segment and uses a different splice site in an adjacent exon when compared to variant 1. The resulting isoform (b) is longer with a different internal protein sequence when compared to isoform a.
    Source sequence(s)
    AA856596, AC019100, AF186255
    Consensus CDS
    CCDS2076.1
    UniProtKB/Swiss-Prot
    O00338
    Related
    ENSP00000319622.5, ENST00000326853.9
    Conserved Domains (1) summary
    pfam00685
    Location:39299
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    108288895..108309915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264013.4XP_005264070.1  sulfotransferase 1C2 isoform X1

    Conserved Domains (1) summary
    pfam00685
    Location:39290
    Sulfotransfer_1; Sulfotransferase domain
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