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Fam135a family with sequence similarity 135, member A [ Mus musculus (house mouse) ]

Gene ID: 68187, updated on 6-Jun-2024

Summary

Official Symbol
Fam135aprovided by MGI
Official Full Name
family with sequence similarity 135, member Aprovided by MGI
Primary source
MGI:MGI:1915437
See related
Ensembl:ENSMUSG00000026153 AllianceGenome:MGI:1915437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921533L14Rik
Summary
Predicted to be involved in cellular lipid metabolic process. Is expressed in neural retinal epithelium; peripheral nervous system; retina layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human FAM135A (family with sequence similarity 135 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 8.2), limb E14.5 (RPKM 7.7) and 26 other tissues See more
Orthologs
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Genomic context

See Fam135a in Genome Data Viewer
Location:
1 A5; 1 9.87 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (24049824..24139444, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (24010758..24100484, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene beta-1,3-glucuronyltransferase 2 Neighboring gene small ArfGAP 1 Neighboring gene STARR-positive B cell enhancer ABC_E981 Neighboring gene predicted gene 53062 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene STARR-seq mESC enhancer starr_00443 Neighboring gene STARR-seq mESC enhancer starr_00445 Neighboring gene predicted gene, 30756 Neighboring gene STARR-seq mESC enhancer starr_00447 Neighboring gene collagen, type IX, alpha 1 Neighboring gene collagen, type XIX, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_00448 Neighboring gene STARR-seq mESC enhancer starr_00450 Neighboring gene STARR-seq mESC enhancer starr_00451 Neighboring gene predicted gene, 26418

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • KIAA1411

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cellular lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403087.1NP_001390016.1  protein FAM135A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/TrEMBL
    A0A087WP54
  2. NM_001403088.1NP_001390017.1  protein FAM135A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/TrEMBL
    A0A087WP54
  3. NM_001403089.1NP_001390018.1  protein FAM135A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/TrEMBL
    A0A087WP54
  4. NM_001403090.1NP_001390019.1  protein FAM135A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/Swiss-Prot
    Q3UEW1, Q5XK31, Q6NS59, Q8BXS8, Q8BZL9, Q8K2K2, Q9D2J6
    UniProtKB/TrEMBL
    A0A087WP54
    Conserved Domains (2) summary
    pfam05057
    Location:12351430
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111172
    DUF3657; Protein FAM135
  5. NM_001403091.1NP_001390020.1  protein FAM135A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/TrEMBL
    A0A087WP54
  6. NM_001403092.1NP_001390021.1  protein FAM135A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/TrEMBL
    A0A087WP54
    Related
    ENSMUSP00000139633.2, ENSMUST00000187752.7
  7. NM_001403093.1NP_001390022.1  protein FAM135A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/TrEMBL
    A0A087WP54
  8. NM_001403094.1NP_001390023.1  protein FAM135A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/TrEMBL
    A0A087WP54, A0A087WRT5
  9. NM_001403095.1NP_001390024.1  protein FAM135A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
    UniProtKB/TrEMBL
    A0A087WP54, A0A087WRT5
    Related
    ENSMUSP00000140766.2, ENSMUST00000187369.7
  10. NM_001403096.1NP_001390025.1  protein FAM135A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
  11. NM_001403097.1NP_001390026.1  protein FAM135A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325
  12. NM_026604.4NP_080880.4  protein FAM135A isoform 3

    See identical proteins and their annotated locations for NP_080880.4

    Status: VALIDATED

    Source sequence(s)
    AK034175, AK044359, BC070446, BM200880, BY732479
    Consensus CDS
    CCDS14853.1
    UniProtKB/Swiss-Prot
    Q3UEW1, Q5XK31, Q6NS59, Q8BXS8, Q8BZL9, Q8K2K2, Q9D2J6
    UniProtKB/TrEMBL
    A0A087WP54
    Related
    ENSMUSP00000027337.9, ENSMUST00000027337.15
    Conserved Domains (2) summary
    pfam05057
    Location:12351430
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111172
    DUF3657; Protein FAM135

RNA

  1. NR_175350.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123790, AC129325

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    24049824..24139444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238569.3XP_011236871.1  protein FAM135A isoform X14

    Conserved Domains (1) summary
    pfam05057
    Location:645840
    DUF676; Putative serine esterase (DUF676)
  2. XM_030242598.2XP_030098458.1  protein FAM135A isoform X11

    Conserved Domains (1) summary
    pfam05057
    Location:8411036
    DUF676; Putative serine esterase (DUF676)
  3. XM_006496232.5XP_006496295.1  protein FAM135A isoform X2

    UniProtKB/TrEMBL
    A0A087WP54
    Conserved Domains (2) summary
    pfam05057
    Location:12391434
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:115175
    DUF3657; Protein FAM135
  4. XM_017322275.3XP_017177764.1  protein FAM135A isoform X6

    UniProtKB/TrEMBL
    A0A087WP54
    Conserved Domains (2) summary
    pfam05057
    Location:10431238
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:115175
    DUF3657; Protein FAM135
  5. XM_030242599.2XP_030098459.1  protein FAM135A isoform X12

    Conserved Domains (1) summary
    pfam05057
    Location:8101005
    DUF676; Putative serine esterase (DUF676)
  6. XM_036153271.1XP_036009164.1  protein FAM135A isoform X10

    Conserved Domains (1) summary
    pfam05057
    Location:8611056
    DUF676; Putative serine esterase (DUF676)
  7. XM_030242596.2XP_030098456.1  protein FAM135A isoform X10

    Conserved Domains (1) summary
    pfam05057
    Location:8611056
    DUF676; Putative serine esterase (DUF676)
  8. XM_030242600.2XP_030098460.1  protein FAM135A isoform X12

    Conserved Domains (1) summary
    pfam05057
    Location:8101005
    DUF676; Putative serine esterase (DUF676)
  9. XM_030242597.1XP_030098457.1  protein FAM135A isoform X10

    Conserved Domains (1) summary
    pfam05057
    Location:8611056
    DUF676; Putative serine esterase (DUF676)

RNA

  1. XR_004934154.1 RNA Sequence