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Pcgf5 polycomb group ring finger 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 681178, updated on 30-May-2026
Official Symbol
Pcgf5provided by RGD
Official Full Name
polycomb group ring finger 5provided by RGD
Primary source
RGD:1583513
See related
Ensembl:ENSRNOG00000018532 AllianceGenome:RGD:1583513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone H2AK119 ubiquitin ligase activity. Predicted to be involved in random inactivation of X chromosome and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including Golgi apparatus; X chromosome; and centrosome. Predicted to be part of PRC1 complex. Orthologous to human PCGF5 (polycomb group ring finger 5). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Testes (RPKM 74.0), Heart (RPKM 64.0) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Pcgf5 in Genome Data Viewer
Location:
1q53
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (243476450..243592603)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (234063854..234180022)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (254974688..255090925)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glutamic acid-rich protein-like Neighboring gene uncharacterized LOC134485230 Neighboring gene ankyrin repeat domain 1 Neighboring gene uncharacterized LOC103691349 Neighboring gene HECT domain E3 ubiquitin protein ligase 2 Neighboring gene uncharacterized LOC134485231

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. Almeida M, et al. Science, 2017 Jun 9. PMID 28596365, Free PMC Article
  2. PRC1 complex diversity: where is it taking us? Gil J, et al. Trends Cell Biol, 2014 Nov. PMID 25065329
  3. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA, et al. Mol Cell, 2013 Mar 7. PMID 23473600, Free PMC Article
  4. An AUTS2-Polycomb complex activates gene expression in the CNS. Gao Z, et al. Nature, 2014 Dec 18. PMID 25519132, Free PMC Article
  5. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Vandamme J, et al. Mol Cell Proteomics, 2011 Apr. PMID 21282530, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC189388

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone H2AK119 ubiquitin ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AK119 ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in random inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
  
involved_in random inactivation of X chromosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PcG protein complex IEA
Inferred from Electronic Annotation
more info
  
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with X chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in X chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
polycomb group RING finger protein 5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129882.2 → NP_001123354.1  polycomb group RING finger protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001123354.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2K8R7, A0A8J8YBC5, B2RZ90, E9PTD5
    Related
    ENSRNOP00000025020.7, ENSRNOT00000025020.8
    Conserved Domains (3) summary
    TIGR00599
    Location:8 → 135
    rad18; DNA repair protein rad18
    cd16737
    Location:16 → 57
    RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
    cd17084
    Location:136 → 236
    RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

  2. NM_001440241.1 → NP_001427170.1  polycomb group RING finger protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2K8R7, A0A8J8YBC5, B2RZ90, E9PTD5

  3. NM_001440242.1 → NP_001427171.1  polycomb group RING finger protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2K8R7, A0A8J8YBC5, B2RZ90, E9PTD5

  4. NM_001440243.1 → NP_001427172.1  polycomb group RING finger protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ASY1, A6I153

  5. NM_001440244.1 → NP_001427173.1  polycomb group RING finger protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ASY1, A6I153

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    243476450..243592603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589708.3 → XP_017445197.1  

    Related
    ENSRNOP00000097432.1, ENSRNOT00000114275.2
    Conserved Domains (2) summary
    pfam00097
    Location:18 → 56
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam16207
    Location:154 → 216
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

  2. XM_006231311.5 → XP_006231373.1  

    Conserved Domains (3) summary
    TIGR00599
    Location:8 → 135
    rad18; DNA repair protein rad18
    cd16737
    Location:16 → 57
    RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
    cd17084
    Location:136 → 236
    RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

  3. XM_017589707.3 → XP_017445196.1  

    Conserved Domains (2) summary
    pfam00097
    Location:18 → 56
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam16207
    Location:154 → 216
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

  4. XM_017589709.3 → XP_017445198.1  polycomb group RING finger protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ASY1, A6I153
    Conserved Domains (2) summary
    pfam00097
    Location:18 → 56
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam16207
    Location:154 → 216
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

  5. XM_063273717.1 → XP_063129787.1  

Nucleotide Protein Strain
Heading Accession and Version

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