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Pwwp3a PWWP domain containing 3A, DNA repair factor [ Mus musculus (house mouse) ]

Gene ID: 68114, updated on 5-Mar-2024

Summary

Official Symbol
Pwwp3aprovided by MGI
Official Full Name
PWWP domain containing 3A, DNA repair factorprovided by MGI
Primary source
MGI:MGI:1915364
See related
Ensembl:ENSMUSG00000020156 AllianceGenome:MGI:1915364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mum1; MUM-1; UBE-1C2; 2610019J09; 9430059D04Rik
Summary
Predicted to enable nucleosome binding activity. Predicted to be involved in DNA repair and chromatin organization. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including foregut; ganglia; midbrain lateral wall; nose; and tooth. Orthologous to human PWWP3A (PWWP domain containing 3A, DNA repair factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 52.6), CNS E11.5 (RPKM 26.1) and 26 other tissues See more
Orthologs
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Genomic context

See Pwwp3a in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80062265..80082415)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80226431..80245144)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E576 Neighboring gene family with sequence similarity 174, member C Neighboring gene ephrin A2 Neighboring gene STARR-positive B cell enhancer ABC_E3898 Neighboring gene nuclear encoded tRNA pheylalanine 3 (anticodon GAA) Neighboring gene nuclear encoded tRNA asparagine 7 (anticodon GTT) Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
PWWP domain-containing DNA repair factor 3A
Names
PWWP domain-containing protein MUM1
melanoma associated antigen (mutated) 1
mutated melanoma-associated antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023431.6NP_075920.4  PWWP domain-containing DNA repair factor 3A

    See identical proteins and their annotated locations for NP_075920.4

    Status: VALIDATED

    Source sequence(s)
    AC140229
    Consensus CDS
    CCDS24014.1
    UniProtKB/Swiss-Prot
    Q3TCZ4, Q6DID5, Q6NST9, Q8C5E3, Q8R1V6, Q9R1R7
    Related
    ENSMUSP00000020365.9, ENSMUST00000020365.15
    Conserved Domains (1) summary
    cd06080
    Location:381460
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80062265..80082415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245246.1XP_030101106.1  PWWP domain-containing DNA repair factor 3A isoform X1

    UniProtKB/Swiss-Prot
    Q3TCZ4, Q6DID5, Q6NST9, Q8C5E3, Q8R1V6, Q9R1R7
    Conserved Domains (1) summary
    cd06080
    Location:381460
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
  2. XM_006514026.2XP_006514089.1  PWWP domain-containing DNA repair factor 3A isoform X2

    Conserved Domains (1) summary
    cd06080
    Location:381460
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...
  3. XM_006514025.3XP_006514088.1  PWWP domain-containing DNA repair factor 3A isoform X1

    See identical proteins and their annotated locations for XP_006514088.1

    UniProtKB/Swiss-Prot
    Q3TCZ4, Q6DID5, Q6NST9, Q8C5E3, Q8R1V6, Q9R1R7
    Conserved Domains (1) summary
    cd06080
    Location:381460
    MUM1_like; Mutated melanoma-associated antigen 1 (MUM-1) is a melanoma-associated antigen (MAA). MUM-1 belongs to the mutated or aberrantly expressed type of MAAs, along with antigens such as CDK4, beta-catenin, gp100-in4, p15, and N-acetylglucosaminyltransferase ...