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Entr1 endosome associated trafficking regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 68112, updated on 30-Apr-2024

Summary

Official Symbol
Entr1provided by MGI
Official Full Name
endosome associated trafficking regulator 1provided by MGI
Primary source
MGI:MGI:1915362
See related
Ensembl:ENSMUSG00000026927 AllianceGenome:MGI:1915362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sdccag3; C330016H24Rik; C630038K21Rik
Summary
Predicted to be involved in several processes, including endocytic recycling; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Predicted to act upstream of or within cell division; cell projection organization; and protein transport. Predicted to be located in endosome. Predicted to be part of retromer complex. Predicted to be active in endosome; microtubule organizing center; and midbody. Orthologous to human ENTR1 (endosome associated trafficking regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 146.9), CNS E18 (RPKM 52.5) and 28 other tissues See more
Orthologs
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Genomic context

See Entr1 in Genome Data Viewer
Location:
2 A3; 2 18.88 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26272810..26279352, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26382798..26389340, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13562 Neighboring gene caspase recruitment domain family, member 9 Neighboring gene small nuclear RNA activating complex, polypeptide 4 Neighboring gene peptidase (mitochondrial processing) alpha Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene STARR-positive B cell enhancer ABC_E5900 Neighboring gene SEC16 homolog A, endoplasmic reticulum export factor Neighboring gene RIKEN cDNA 0610009E02 gene Neighboring gene STARR-positive B cell enhancer ABC_E1241

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein localization to cilium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endosome-associated-trafficking regulator 1
Names
serologically defined colon cancer antigen 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085407.1NP_001078876.1  endosome-associated-trafficking regulator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK082787, AK163690, BY104480
    Consensus CDS
    CCDS50541.1
    UniProtKB/Swiss-Prot
    A2AIW0
    Related
    ENSMUSP00000028293.6, ENSMUST00000028293.12
    Conserved Domains (1) summary
    pfam16034
    Location:147317
    JAKMIP_CC3; JAKMIP CC3 domain
  2. NM_001085408.1NP_001078877.1  endosome-associated-trafficking regulator 1 isoform 4

    See identical proteins and their annotated locations for NP_001078877.1

    Status: VALIDATED

    Source sequence(s)
    AK163690, AW743523, BY104480
    Consensus CDS
    CCDS50540.1
    UniProtKB/Swiss-Prot
    A2AIW0
    Related
    ENSMUSP00000077133.7, ENSMUST00000077983.13
    Conserved Domains (1) summary
    pfam16034
    Location:124294
    JAKMIP_CC3; JAKMIP CC3 domain
  3. NM_026563.3NP_080839.2  endosome-associated-trafficking regulator 1 isoform 1

    See identical proteins and their annotated locations for NP_080839.2

    Status: VALIDATED

    Source sequence(s)
    AK014885, AK163690, BY104480
    Consensus CDS
    CCDS15803.2
    UniProtKB/Swiss-Prot
    A2AIW0, A2AIW1, Q3TQC5, Q6P8W2, Q8BIV5, Q8K0I8, Q9D1V2, Q9D4S1, Q9D5W1
    Related
    ENSMUSP00000109737.4, ENSMUST00000114102.10
    Conserved Domains (1) summary
    pfam16034
    Location:197367
    JAKMIP_CC3; JAKMIP CC3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26272810..26279352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252001.1XP_030107861.1  endosome-associated-trafficking regulator 1 isoform X3

    Conserved Domains (1) summary
    TIGR02169
    Location:186285
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  2. XM_006498261.2XP_006498324.1  endosome-associated-trafficking regulator 1 isoform X1

    Conserved Domains (1) summary
    pfam15898
    Location:269357
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  3. XM_030252003.1XP_030107863.1  endosome-associated-trafficking regulator 1 isoform X5

    Conserved Domains (1) summary
    TIGR02169
    Location:106205
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  4. XM_006498262.5XP_006498325.1  endosome-associated-trafficking regulator 1 isoform X2

    UniProtKB/TrEMBL
    A2AIW3
    Related
    ENSMUSP00000109735.4, ENSMUST00000114100.10
    Conserved Domains (1) summary
    TIGR02168
    Location:228350
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  5. XM_030252002.2XP_030107862.1  endosome-associated-trafficking regulator 1 isoform X4

    Conserved Domains (1) summary
    TIGR02168
    Location:98220
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  6. XM_036162513.1XP_036018406.1  endosome-associated-trafficking regulator 1 isoform X4

    Conserved Domains (1) summary
    TIGR02168
    Location:98220
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_003953706.1 RNA Sequence

  2. XR_003953705.2 RNA Sequence

  3. XR_003953703.2 RNA Sequence

  4. XR_003953704.2 RNA Sequence

  5. XR_004940714.1 RNA Sequence

  6. XR_374113.2 RNA Sequence

  7. XR_374114.2 RNA Sequence

  8. XR_003953702.1 RNA Sequence

  9. XR_004940713.1 RNA Sequence

  10. XR_004940712.1 RNA Sequence

  11. XR_003953701.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030155.2: Suppressed sequence

    Description
    NM_030155.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript, and it contains a deletion compared to available sequence data that results in a frameshift.