Format

Send to:

Choose Destination

STX4 syntaxin 4 [ Homo sapiens (human) ]

Gene ID: 6810, updated on 7-Jun-2020

Summary

Official Symbol
STX4provided by HGNC
Official Full Name
syntaxin 4provided by HGNC
Primary source
HGNC:HGNC:11439
See related
Ensembl:ENSG00000103496 MIM:186591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STX4A; p35-2
Expression
Ubiquitous expression in spleen (RPKM 17.8), adrenal (RPKM 16.5) and 25 other tissues See more
Orthologs

Genomic context

See STX4 in Genome Data Viewer
Location:
16p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (31033095..31040168)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31044416..31051489)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Neighboring gene syntaxin 1B Neighboring gene uncharacterized LOC101928762 Neighboring gene zinc finger protein 668 Neighboring gene zinc finger protein 646

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sphingomyelin phosphodiesterase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
SNARE complex assembly IEA
Inferred from Electronic Annotation
more info
 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
cornified envelope assembly IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-term synaptic potentiation IDA
Inferred from Direct Assay
more info
PubMed 
organelle fusion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of eosinophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of immunoglobulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
lateral loop IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath adaxonal region IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
somatodendritic compartment IDA
Inferred from Direct Assay
more info
PubMed 
specific granule IDA
Inferred from Direct Assay
more info
PubMed 
storage vacuole IEA
Inferred from Electronic Annotation
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
vacuole TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
syntaxin-4
Names
renal carcinoma antigen NY-REN-31
syntaxin 4A (placental)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272095.1NP_001259024.1  syntaxin-4 isoform 1

    See identical proteins and their annotated locations for NP_001259024.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest protein (isoform 1).
    Source sequence(s)
    AK296652, BI755734, BQ775670
    UniProtKB/TrEMBL
    B7Z425
    Conserved Domains (2) summary
    cd00179
    Location:1111
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cl22856
    Location:121183
    SNARE; SNARE motif
  2. NM_001272096.1NP_001259025.1  syntaxin-4 isoform 2

    See identical proteins and their annotated locations for NP_001259025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR, initiates translation at an alternate upstream start codon and uses alternate splice sites at internal exons, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK091833, BC002436, BQ775670
    Consensus CDS
    CCDS61916.1
    UniProtKB/Swiss-Prot
    Q12846
    Related
    ENSP00000378447.1, ENST00000394998.5
    Conserved Domains (2) summary
    cd00179
    Location:42187
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15883
    Location:197259
    SNARE_syntaxin4; SNARE motif of syntaxin 4
  3. NM_004604.5NP_004595.2  syntaxin-4 isoform 3

    See identical proteins and their annotated locations for NP_004595.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) initiates translation at an alternate downstream start codon and uses alternate splice sites at internal exons, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    BC002436, BI755734
    Consensus CDS
    CCDS10700.1
    UniProtKB/Swiss-Prot
    Q12846
    Related
    ENSP00000317714.3, ENST00000313843.8
    Conserved Domains (2) summary
    cd00179
    Location:39189
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15883
    Location:199261
    SNARE_syntaxin4; SNARE motif of syntaxin 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    31033095..31040168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255521.1XP_005255578.1  syntaxin-4 isoform X1

    See identical proteins and their annotated locations for XP_005255578.1

    Conserved Domains (3) summary
    cd00179
    Location:40185
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15883
    Location:195257
    SNARE_syntaxin4; SNARE motif of syntaxin 4
    pfam00804
    Location:40231
    Syntaxin; Syntaxin

RNA

  1. XR_002957836.1 RNA Sequence

  2. XR_002957837.1 RNA Sequence

  3. XR_002957838.1 RNA Sequence

Support Center