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Rchy1 ring finger and CHY zinc finger domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 68098, updated on 9-May-2024

Summary

Official Symbol
Rchy1provided by MGI
Official Full Name
ring finger and CHY zinc finger domain containing 1provided by MGI
Primary source
MGI:MGI:1915348
See related
Ensembl:ENSMUSG00000029397 AllianceGenome:MGI:1915348
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARNIP; CHIMP; Pirh2; Zfp363; Znf363
Summary
This gene encodes a protein containing CHY-, CTCHY-, and RING-type zinc-fingers. The encoded protein functions as an E3 ubiquitin ligase, and mediates the degradation of target proteins such as p53. The activity of this protein is important in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in bladder adult (RPKM 12.9), CNS E14 (RPKM 12.2) and 28 other tissues See more
Orthologs
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Genomic context

See Rchy1 in Genome Data Viewer
Location:
5 E2; 5 45.58 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92096701..92110988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (91948842..91963145, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36303 Neighboring gene predicted gene, 36357 Neighboring gene STARR-seq mESC enhancer starr_13621 Neighboring gene STARR-seq mESC enhancer starr_13622 Neighboring gene STARR-seq mESC enhancer starr_13623 Neighboring gene THAP domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_13624 Neighboring gene odontogenesis associated phosphoprotein Neighboring gene cyclin dependent kinase like 2 Neighboring gene predicted gene, 46915

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RING finger and CHY zinc finger domain-containing protein 1
Names
CH-rich-interacting match with PLAG1
E3 ubiquitin-protein ligase Pirh2
RING-type E3 ubiquitin transferase RCHY1
androgen receptor N-terminal-interacting protein
zinc finger protein 363
NP_001258726.1
NP_001408145.1
NP_080833.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271797.2NP_001258726.1  RING finger and CHY zinc finger domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001258726.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC165433
    Consensus CDS
    CCDS71613.1
    UniProtKB/TrEMBL
    G3UWD8, Q8R593
    Related
    ENSMUSP00000131270.2, ENSMUST00000169948.2
    Conserved Domains (2) summary
    pfam13639
    Location:104146
    zf-RING_2; Ring finger domain
    pfam14599
    Location:151209
    zinc_ribbon_6; Zinc-ribbon
  2. NM_001421216.1NP_001408145.1  RING finger and CHY zinc finger domain-containing protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC165433
  3. NM_026557.5NP_080833.1  RING finger and CHY zinc finger domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_080833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC165433
    Consensus CDS
    CCDS19424.1
    UniProtKB/Swiss-Prot
    Q920H0, Q9CR50
    UniProtKB/TrEMBL
    Q8R593
    Related
    ENSMUSP00000031345.9, ENSMUST00000031345.15
    Conserved Domains (3) summary
    pfam05495
    Location:2093
    zf-CHY; CHY zinc finger
    pfam13639
    Location:144186
    zf-RING_2; Ring finger domain
    pfam14599
    Location:191249
    zinc_ribbon_6; Zinc-ribbon

RNA

  1. NR_073442.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' exon structure, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK015870, AK018488, AK078397
    Related
    ENSMUST00000140670.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    92096701..92110988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)