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Lurap1 leucine rich adaptor protein 1 [ Mus musculus (house mouse) ]

Gene ID: 68075, updated on 2-Nov-2024

Summary

Official Symbol
Lurap1provided by MGI
Official Full Name
leucine rich adaptor protein 1provided by MGI
Primary source
MGI:MGI:1915325
See related
Ensembl:ENSMUSG00000028701 AllianceGenome:MGI:1915325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrp35a; 1520402A15Rik
Summary
Predicted to be involved in several processes, including actomyosin structure organization; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of cytokine production. Predicted to be located in actomyosin; cytosol; and intracellular membrane-bounded organelle. Orthologous to human LURAP1 (leucine rich adaptor protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 13.6), testis adult (RPKM 7.1) and 23 other tissues See more
Orthologs
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Genomic context

See Lurap1 in Genome Data Viewer
Location:
4 D1; 4 53.1 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115993925..116001813, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116136728..116144616, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 41 Neighboring gene predicted gene, 52704 Neighboring gene RAD54 like (S. cerevisiae) Neighboring gene RIKEN cDNA 2510003B16 gene Neighboring gene STARR-positive B cell enhancer ABC_E10248 Neighboring gene STARR-seq mESC enhancer starr_11132 Neighboring gene protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase Neighboring gene tetraspanin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in actomyosin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leucine rich adaptor protein 1
Names
NF-kappa-B activator C1orf190 homolog
leucine repeat adapter protein 35A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026547.1NP_080823.1  leucine rich adaptor protein 1

    See identical proteins and their annotated locations for NP_080823.1

    Status: VALIDATED

    Source sequence(s)
    AL611947, BB749015, BC147750
    Consensus CDS
    CCDS51275.1
    UniProtKB/Swiss-Prot
    Q9D6I9
    UniProtKB/TrEMBL
    A2A8F6
    Related
    ENSMUSP00000030469.5, ENSMUST00000030469.5
    Conserved Domains (1) summary
    pfam14854
    Location:39159
    LURAP; Leucine rich adaptor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115993925..116001813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)