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Atpsckmt ATP synthase C subunit lysine N-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 68073, updated on 18-Feb-2023

Summary

Official Symbol
Atpsckmtprovided by MGI
Official Full Name
ATP synthase C subunit lysine N-methyltransferaseprovided by MGI
Primary source
MGI:MGI:1915323
See related
Ensembl:ENSMUSG00000039065 AllianceGenome:MGI:1915323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam173b; mFam173b; A930016P21Rik
Summary
Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation; positive regulation of sensory perception of pain; and regulation of proton transport. Predicted to be located in mitochondrial crista. Predicted to be active in mitochondrion. Orthologous to human ATPSCKMT (ATP synthase c subunit lysine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.0), CNS E11.5 (RPKM 6.0) and 28 other tissues See more
Orthologs
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Genomic context

See Atpsckmt in Genome Data Viewer
Location:
15; 15 B2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (31602262..31624652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (31602116..31617537)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene carboxymethylenebutenolidase-like (Pseudomonas) Neighboring gene chaperonin containing Tcp1, subunit 5 (epsilon) Neighboring gene predicted gene, 32383 Neighboring gene predicted gene, 53869 Neighboring gene predicted gene, 46522

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-lysine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-lysine methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-lysine trimethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine trimethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine trimethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proton-transporting ATP synthase activity, rotational mechanism IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial ATP synthesis coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitochondrial ATP synthesis coupled proton transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrial ATP synthesis coupled proton transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial crista ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP synthase subunit C lysine N-methyltransferase
Names
family with sequence similarity 173, member B
protein FAM173B
protein N-lysine methyltransferase FAM173B
NP_001343242.1
NP_080822.1
XP_030104583.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356313.1NP_001343242.1  ATP synthase subunit C lysine N-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC137842
    Consensus CDS
    CCDS88746.1
    UniProtKB/TrEMBL
    E0CXY7
    Related
    ENSMUSP00000124619.3, ENSMUST00000161061.3
    Conserved Domains (1) summary
    TIGR02021
    Location:979
    BchM-ChlM; magnesium protoporphyrin O-methyltransferase
  2. NM_026546.3NP_080822.1  ATP synthase subunit C lysine N-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_080822.1

    Status: VALIDATED

    Source sequence(s)
    AC137842
    Consensus CDS
    CCDS27412.1
    UniProtKB/Swiss-Prot
    Q8K2S1, Q9D1Z3
    Related
    ENSMUSP00000039094.7, ENSMUST00000042702.7
    Conserved Domains (1) summary
    TIGR02021
    Location:87157
    BchM-ChlM; magnesium protoporphyrin O-methyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    31602262..31624652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248723.2XP_030104583.1  ATP synthase subunit C lysine N-methyltransferase isoform X1

    UniProtKB/TrEMBL
    E0CXY7
    Conserved Domains (1) summary
    TIGR02021
    Location:979
    BchM-ChlM; magnesium protoporphyrin O-methyltransferase