U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mrnip MRN complex interacting protein [ Mus musculus (house mouse) ]

Gene ID: 68067, updated on 8-May-2024

Summary

Official Symbol
Mrnipprovided by MGI
Official Full Name
MRN complex interacting proteinprovided by MGI
Primary source
MGI:MGI:1915317
See related
Ensembl:ENSMUSG00000020381 AllianceGenome:MGI:1915317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900016G09Rik; 3010026O09Rik
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; regulation of double-strand break repair; and response to ionizing radiation. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleoplasm. Predicted to be part of Mre11 complex. Predicted to be active in nucleus. Orthologous to human MRNIP (MRN complex interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 3.7), placenta adult (RPKM 3.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mrnip in Genome Data Viewer
Location:
11 B1.3; 11 30.33 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50065678..50090943)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50174851..50200116)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene TBC1 domain family, member 9B Neighboring gene predicted gene, 53700 Neighboring gene STARR-positive B cell enhancer ABC_E1823 Neighboring gene sequestosome 1 Neighboring gene STARR-positive B cell enhancer ABC_E6977 Neighboring gene STARR-seq mESC enhancer starr_29389 Neighboring gene STARR-seq mESC enhancer starr_29391 Neighboring gene predicted gene, 36556

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Mre11 complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
MRN complex-interacting protein
Names
MRN-interacting protein
UPF0544 protein C5orf45 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026543.3NP_080819.2  MRN complex-interacting protein

    See identical proteins and their annotated locations for NP_080819.2

    Status: VALIDATED

    Source sequence(s)
    AK019392, BC028428
    Consensus CDS
    CCDS48784.1
    UniProtKB/Swiss-Prot
    Q9CX85, Q9D1F5
    Related
    ENSMUSP00000020647.4, ENSMUST00000020647.10
    Conserved Domains (1) summary
    pfam15749
    Location:9107
    UPF0544; uncharacterized protein family UPF0544

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50065678..50090943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534037.5XP_006534100.1  MRN complex-interacting protein isoform X1