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Slc25a39 solute carrier family 25, member 39 [ Mus musculus (house mouse) ]

Gene ID: 68066, updated on 24-Jan-2023

Summary

Official Symbol
Slc25a39provided by MGI
Official Full Name
solute carrier family 25, member 39provided by MGI
Primary source
MGI:MGI:1196386
See related
Ensembl:ENSMUSG00000018677 AllianceGenome:MGI:1196386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D11Ertd333e; 3010027G13Rik
Summary
Predicted to act upstream of or within heme biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and skeleton. Orthologous to human SLC25A39 (solute carrier family 25 member 39). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 285.8), kidney adult (RPKM 222.5) and 25 other tissues See more
Orthologs
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Genomic context

See Slc25a39 in Genome Data Viewer
Location:
11 D; 11 66.29 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102293795..102299501, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102402969..102408675, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Bloodlinc, erythroid developmental long intergenic non-protein coding transcript Neighboring gene predicted gene, 34253 Neighboring gene RUN domain containing 3A Neighboring gene microRNA 6930 Neighboring gene granulin Neighboring gene family with sequence similarity 171, member A2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3)  1 citation

General gene information

Markers

Homology

Clone Names

  • MGC144572, MGC144573

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in glutathione import into mitochondrion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable mitochondrial glutathione transporter SLC25A39; solute carrier family 25 member 39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026542.3NP_080818.1  probable mitochondrial glutathione transporter SLC25A39

    See identical proteins and their annotated locations for NP_080818.1

    Status: VALIDATED

    Source sequence(s)
    AK161289, BU758028, BY291748
    Consensus CDS
    CCDS25498.1
    UniProtKB/Swiss-Prot
    Q3TTM8, Q9D8K8
    UniProtKB/TrEMBL
    A0A8C6I9S2, Q14BQ5
    Related
    ENSMUSP00000018821.3, ENSMUST00000018821.9
    Conserved Domains (2) summary
    pfam00153
    Location:254350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:7194
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102293795..102299501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534035.1XP_006534098.1  solute carrier family 25 member 39 isoform X1

    See identical proteins and their annotated locations for XP_006534098.1

    UniProtKB/Swiss-Prot
    Q3TTM8, Q9D8K8
    UniProtKB/TrEMBL
    A0A8C6I9S2, Q14BQ5
    Conserved Domains (2) summary
    pfam00153
    Location:254350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:7194
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade
  2. XM_006534036.4XP_006534099.1  solute carrier family 25 member 39 isoform X2

    Related
    ENSMUSP00000115445.2, ENSMUST00000155104.8
    Conserved Domains (2) summary
    pfam00153
    Location:9152
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:7194
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade
  3. XM_006534034.2XP_006534097.1  solute carrier family 25 member 39 isoform X1

    See identical proteins and their annotated locations for XP_006534097.1

    UniProtKB/Swiss-Prot
    Q3TTM8, Q9D8K8
    UniProtKB/TrEMBL
    A0A8C6I9S2, Q14BQ5
    Conserved Domains (2) summary
    pfam00153
    Location:254350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:7194
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade
  4. XM_030246255.1XP_030102115.1  solute carrier family 25 member 39 isoform X1

    UniProtKB/Swiss-Prot
    Q3TTM8
    UniProtKB/TrEMBL
    A0A8C6I9S2, Q14BQ5
    Conserved Domains (2) summary
    pfam00153
    Location:254350
    Mito_carr; Mitochondrial carrier protein
    pfam18398
    Location:7194
    CLIP_SPH_mas; Clip-domain serine protease homolog masquerade
  5. XM_030246256.1XP_030102116.1  solute carrier family 25 member 39 isoform X3

    Conserved Domains (1) summary
    pfam00153
    Location:153249
    Mito_carr; Mitochondrial carrier protein