U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ebi3 Epstein-Barr virus induced 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680609, updated on 24-Jul-2025
Official Symbol
Ebi3provided by RGD
Official Full Name
Epstein-Barr virus induced 3provided by RGD
Primary source
RGD:1589467
See related
Ensembl:ENSRNOG00000050509 AllianceGenome:RGD:1589467
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytokine receptor activity and interleukin-27 receptor binding activity. Predicted to be involved in T cell proliferation. Predicted to be located in membrane. Biomarker of pre-eclampsia. Orthologous to human EBI3 (Epstein-Barr virus induced 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Spleen (RPKM 23.8), Thymus (RPKM 6.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See Ebi3 in Genome Data Viewer
Location:
9q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (861441..874731)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (774252..787544)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (11110874..11114843, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S8, pseudogene 14 Neighboring gene UDP-glucuronate decarboxylase 1 Neighboring gene zinc finger protein 119b like Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ribosomal protein S21, pseudogene 2 Neighboring gene uncharacterized LOC134480467 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation. Dokmeci E, et al. Immunology, 2011 Apr. PMID 21255010, Free PMC Article
  2. The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint. Houshmandi N, et al. Cytokine, 2016 May. PMID 26994309
  3. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Devergne O, et al. Proc Natl Acad Sci U S A, 1997 Oct 28. PMID 9342359, Free PMC Article
  4. Metformin exhibits its therapeutic effect in the treatment of pre-eclampsia via modulating the Met/H19/miR-148a-5p/P28 and Met/H19/miR-216-3p/EBI3 signaling pathways. Shu C, et al. Int Immunopharmacol, 2019 Sep. PMID 31203154
  5. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Pflanz S, et al. Immunity, 2002 Jun. PMID 12121660

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that endogenous interleukins IL-27 and IL-35 (Ebi3 and Il-12p35 subunits) had inflammatory roles and insulin like growth factor -1 (IGF-1) had no effect.
    Title: The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables cytokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-27 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-27 receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-27 receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
interleukin-27 subunit beta
Names
Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109421.2 → NP_001102891.1  interleukin-27 subunit beta precursor

    See identical proteins and their annotated locations for NP_001102891.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A6KR24, M0RD76
    Related
    ENSRNOP00000067573.1, ENSRNOT00000072031.3
    Conserved Domains (1) summary
    cd00063
    Location:128 → 216
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    861441..874731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267725.1 → XP_063123795.1  interleukin-27 subunit beta isoform X1

  2. XM_039084203.1 → XP_038940131.1  interleukin-27 subunit beta isoform X2

    Conserved Domains (1) summary
    cd00063
    Location:34 → 122
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous