U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sapcd2 suppressor APC domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680531, updated on 3-Jun-2026
Official Symbol
Sapcd2provided by RGD
Official Full Name
suppressor APC domain containing 2provided by RGD
Primary source
RGD:1590629
See related
Ensembl:ENSRNOG00000013069 AllianceGenome:RGD:1590629
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including establishment of mitotic spindle orientation; negative regulation of protein localization to cell cortex; and regulation of establishment of planar polarity. Predicted to be located in several cellular components, including apical cortex; apical junction complex; and nuclear lumen. Orthologous to human SAPCD2 (suppressor APC domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Thymus (RPKM 37.0), Spleen (RPKM 13.7) and 8 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Sapcd2 in Genome Data Viewer
Location:
3p13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28583615..28590694)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8186089..8195119)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2590355..2597283)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene dipeptidylpeptidase 7 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2 Neighboring gene neural proliferation, differentiation and control, 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Overexpression of p42.3 promotes cell growth and tumorigenicity in hepatocellular carcinoma. Sun W, et al. World J Gastroenterol, 2013 May 21. PMID 23704824, Free PMC Article
  2. p42.3: a promising biomarker for the progression and prognosis of human colorectal cancer. Yuan XS, et al. J Cancer Res Clin Oncol, 2013 Jul. PMID 23576022, Free PMC Article
  3. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Chiu CWN, et al. Dev Cell, 2016 Jan 11. PMID 26766442
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in establishment of mitotic spindle orientation IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to cell cortex IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment of planar polarity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of establishment of planar polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in symmetric cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in symmetric cell division ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical cortex IEA
Inferred from Electronic Annotation
more info
  
located_in apical cortex ISO
Inferred from Sequence Orthology
more info
  
located_in apical junction complex IEA
Inferred from Electronic Annotation
more info
  
located_in apical junction complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
suppressor APC domain-containing protein 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109418.2 → NP_001102888.1  suppressor APC domain-containing protein 2

    See identical proteins and their annotated locations for NP_001102888.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158701
    UniProtKB/TrEMBL
    B0BN66, F7EPX4
    Related
    ENSRNOP00000017466.2, ENSRNOT00000017466.5
    Conserved Domains (1) summary
    pfam11414
    Location:224 → 305
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28583615..28590694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761607.4 → XP_008759829.1  suppressor APC domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    pfam11414
    Location:257 → 338
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools