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STX1A syntaxin 1A [ Homo sapiens (human) ]

Gene ID: 6804, updated on 21-Dec-2019

Summary

Official Symbol
STX1Aprovided by HGNC
Official Full Name
syntaxin 1Aprovided by HGNC
Primary source
HGNC:HGNC:11433
See related
Ensembl:ENSG00000106089 MIM:186590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STX1; HPC-1; P35-1; SYN1A
Summary
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Expression
Biased expression in brain (RPKM 28.2), bone marrow (RPKM 2.7) and 3 other tissues See more
Orthologs

Genomic context

See STX1A in Genome Data Viewer
Location:
7q11.23
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (73699210..73719673, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (73113535..73134032, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C30 Neighboring gene BUD23 rRNA methyltransferase and ribosome maturation factor Neighboring gene uncharacterized LOC105375350 Neighboring gene microRNA 4284 Neighboring gene Sharpr-MPRA regulatory region 8580 Neighboring gene RNA, 7SL, cytoplasmic 265, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
myosin head/neck binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
SNARE complex assembly IEA
Inferred from Electronic Annotation
more info
 
calcium ion regulated exocytosis IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamate secretion TAS
Traceable Author Statement
more info
 
insulin secretion IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter secretion TAS
Traceable Author Statement
more info
 
positive regulation of calcium ion-dependent exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of catecholamine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of norepinephrine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to membrane IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin secretion TAS
Traceable Author Statement
more info
PubMed 
regulation of synaptic vesicle priming IEA
Inferred from Electronic Annotation
more info
 
response to gravity IEA
Inferred from Electronic Annotation
more info
 
secretion by cell IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle docking IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
SNARE complex TAS
Traceable Author Statement
more info
PubMed 
actomyosin IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
Inferred from Electronic Annotation
more info
 
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IEA
Inferred from Electronic Annotation
more info
 
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
syntaxin-1A
Names
neuron-specific antigen HPC-1
syntaxin 1A (brain)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013360.1 RefSeqGene

    Range
    5019..25478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001165903.2NP_001159375.1  syntaxin-1A isoform 2

    See identical proteins and their annotated locations for NP_001159375.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 3' coding region, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC000444, BC064644, DA159446
    Consensus CDS
    CCDS55120.1
    UniProtKB/Swiss-Prot
    Q16623
    Related
    ENSP00000378585.3, ENST00000395156.7
    Conserved Domains (1) summary
    pfam00804
    Location:30226
    Syntaxin; Syntaxin
  2. NM_004603.4NP_004594.1  syntaxin-1A isoform 1

    See identical proteins and their annotated locations for NP_004594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC003011, BC064644, DA159446
    Consensus CDS
    CCDS34655.1
    UniProtKB/Swiss-Prot
    Q16623
    UniProtKB/TrEMBL
    Q75ME0
    Related
    ENSP00000222812.3, ENST00000222812.8
    Conserved Domains (2) summary
    pfam00804
    Location:30227
    Syntaxin; Syntaxin
    pfam05739
    Location:228279
    SNARE; SNARE domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    73699210..73719673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012567.2XP_016868056.1  syntaxin-1A isoform X1

RNA

  1. XR_242263.2 RNA Sequence

  2. XR_927527.2 RNA Sequence

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