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STX1A syntaxin 1A [ Homo sapiens (human) ]

Gene ID: 6804, updated on 22-Sep-2022

Summary

Official Symbol
STX1Aprovided by HGNC
Official Full Name
syntaxin 1Aprovided by HGNC
Primary source
HGNC:HGNC:11433
See related
Ensembl:ENSG00000106089 MIM:186590; AllianceGenome:HGNC:11433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STX1; HPC-1; P35-1; SYN1A
Summary
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Expression
Biased expression in brain (RPKM 28.2), bone marrow (RPKM 2.7) and 3 other tissues See more
Orthologs
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Genomic context

See STX1A in Genome Data Viewer
Location:
7q11.23
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (73699210..73719669, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (74900126..74920586, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (73113540..73133999, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C30 Neighboring gene BUD23 rRNA methyltransferase and ribosome maturation factor Neighboring gene uncharacterized LOC105375350 Neighboring gene microRNA 4284 Neighboring gene Sharpr-MPRA regulatory region 8580 Neighboring gene RNA, 7SL, cytoplasmic 265, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
enables chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables myosin head/neck binding IEA
Inferred from Electronic Annotation
more info
 
enables protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in SNARE complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-ion regulated exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of calcium ion-dependent exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of catecholamine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of norepinephrine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of insulin secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of synaptic vesicle priming IEA
Inferred from Electronic Annotation
more info
 
involved_in response to gravity IEA
Inferred from Electronic Annotation
more info
 
involved_in secretion by cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle docking IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SNARE complex TAS
Traceable Author Statement
more info
PubMed 
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in actomyosin IEA
Inferred from Electronic Annotation
more info
 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
Inferred from Electronic Annotation
more info
 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IEA
Inferred from Electronic Annotation
more info
 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
syntaxin-1A
Names
neuron-specific antigen HPC-1
syntaxin 1A (brain)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013360.1 RefSeqGene

    Range
    5019..25478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001165903.2NP_001159375.1  syntaxin-1A isoform 2

    See identical proteins and their annotated locations for NP_001159375.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 3' coding region, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC000444, BC064644, DA159446
    Consensus CDS
    CCDS55120.1
    UniProtKB/Swiss-Prot
    Q16623
    Related
    ENSP00000378585.3, ENST00000395156.7
    Conserved Domains (1) summary
    pfam00804
    Location:30226
    Syntaxin; Syntaxin
  2. NM_004603.4NP_004594.1  syntaxin-1A isoform 1

    See identical proteins and their annotated locations for NP_004594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC003011, BC064644, DA159446
    Consensus CDS
    CCDS34655.1
    UniProtKB/Swiss-Prot
    Q16623, Q9BPZ6
    UniProtKB/TrEMBL
    Q75ME0
    Related
    ENSP00000222812.3, ENST00000222812.8
    Conserved Domains (2) summary
    pfam00804
    Location:30227
    Syntaxin
    pfam05739
    Location:228279
    SNARE; SNARE domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    73699210..73719669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420778.1XP_047276734.1  syntaxin-1A isoform X2

    UniProtKB/TrEMBL
    A0A0C4DFZ1
    Related
    ENSP00000378584.3, ENST00000395155.3
  2. XM_047420777.1XP_047276733.1  syntaxin-1A isoform X1

    UniProtKB/TrEMBL
    A8MZ54
    Related
    ENSP00000378583.3, ENST00000395154.7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    74900126..74920586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)