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Emc4 ER membrane protein complex subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 68032, updated on 23-Apr-2025

Summary

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Official Symbol
Emc4provided by MGI
Official Full Name
ER membrane protein complex subunit 4provided by MGI
Primary source
MGI:MGI:1915282
See related
Ensembl:ENSMUSG00000027131 AllianceGenome:MGI:1915282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem85; 2610318K02Rik
Summary
Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is expressed in lung. Orthologous to human EMC4 (ER membrane protein complex subunit 4). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in cerebellum adult (RPKM 57.7), cortex adult (RPKM 48.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Emc4 in Genome Data Viewer
Location:
2 E3; 2 57.02 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112193349..112209532, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112363019..112379476, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4485 Neighboring gene STARR-positive B cell enhancer ABC_E7845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:112106464-112106665 Neighboring gene STARR-positive B cell enhancer ABC_E10129 Neighboring gene solute carrier family 12, member 6 Neighboring gene NOP10 ribonucleoprotein Neighboring gene predicted gene, 39908 Neighboring gene STARR-positive B cell enhancer mm9_chr2:112219168-112219469 Neighboring gene katanin p80 subunit B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5959 Neighboring gene STARR-positive B cell enhancer ABC_E3389 Neighboring gene STARR-positive B cell enhancer ABC_E11150 Neighboring gene ER membrane protein complex subunit 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. Tang X, et al. iScience, 2023 Jan 20. PMID 36624844, Free PMC Article
  2. EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. Tang X, et al. J Clin Invest, 2017 Dec 1. PMID 29083321, Free PMC Article
  3. The ER membrane protein complex is a transmembrane domain insertase. Guna A, et al. Science, 2018 Jan 26. PMID 29242231, Free PMC Article
  4. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to membrane insertase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex ISO
Inferred from Sequence Orthology
more info
  
part_of EMC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ER membrane protein complex subunit 4
Names
transmembrane protein 85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418608.1 → NP_001405537.1  ER membrane protein complex subunit 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL683897

  2. NM_001418609.1 → NP_001405538.1  ER membrane protein complex subunit 4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL683897

  3. NM_001418610.1 → NP_001405539.1  ER membrane protein complex subunit 4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL683897

  4. NM_001418611.1 → NP_001405540.1  ER membrane protein complex subunit 4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL683897

  5. NM_001418612.1 → NP_001405541.1  ER membrane protein complex subunit 4 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL683897

  6. NM_001418613.1 → NP_001405542.1  ER membrane protein complex subunit 4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL683897

  7. NM_001418614.1 → NP_001405543.1  ER membrane protein complex subunit 4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL683897

  8. NM_001418615.1 → NP_001405544.1  ER membrane protein complex subunit 4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL683897

  9. NM_001418616.1 → NP_001405545.1  ER membrane protein complex subunit 4 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL683897

  10. NM_001418617.1 → NP_001405546.1  ER membrane protein complex subunit 4 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL683897

  11. NM_026519.4 → NP_080795.1  ER membrane protein complex subunit 4 isoform a

    See identical proteins and their annotated locations for NP_080795.1

    Status: VALIDATED

    Source sequence(s)
    AL683897
    Consensus CDS
    CCDS16553.1
    UniProtKB/Swiss-Prot
    A2AGJ7, Q9CZX9, Q9D1D9
    Related
    ENSMUSP00000028551.4, ENSMUST00000028551.4
    Conserved Domains (1) summary
    pfam06417
    Location:56 → 170
    DUF1077; Protein of unknown function (DUF1077)

RNA

  1. NR_184785.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683897

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    112193349..112209532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252000.2 → XP_030107860.1  ER membrane protein complex subunit 4 isoform X1

    UniProtKB/Swiss-Prot
    A2AGJ7, Q9CZX9, Q9D1D9
    Conserved Domains (1) summary
    pfam06417
    Location:56 → 170
    DUF1077; Protein of unknown function (DUF1077)

  2. XM_030251999.2 → XP_030107859.1  ER membrane protein complex subunit 4 isoform X1

    UniProtKB/Swiss-Prot
    A2AGJ7, Q9CZX9, Q9D1D9
    Conserved Domains (1) summary
    pfam06417
    Location:56 → 170
    DUF1077; Protein of unknown function (DUF1077)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZX9.1 GenPept UniProtKB/Swiss-Prot:Q9CZX9

Gene LinkOut

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