Emc4 ER membrane protein complex subunit 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Emc4provided by MGI
Official Full Name: ER membrane protein complex subunit 4provided by MGI
Primary source: MGI:MGI:1915282
See related: Ensembl:ENSMUSG00000027131 AllianceGenome:MGI:1915282
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmem85; 2610318K02Rik
Summary: Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to act upstream of or within apoptotic process. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is expressed in lung. Orthologous to human EMC4 (ER membrane protein complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 57.7), cortex adult (RPKM 48.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 E3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (112193364..112209532, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (112363019..112379476, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Emc4 gene: The Emc4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 436 organisms have orthologs with human gene Emc4
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to membrane insertase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of EMC complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ER membrane protein complex subunit 4

Names: transmembrane protein 85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026519.3 → NP_080795.1 ER membrane protein complex subunit 4

See identical proteins and their annotated locations for NP_080795.1

Status: PROVISIONAL

Source sequence(s)

AL683897

Consensus CDS

CCDS16553.1

UniProtKB/Swiss-Prot

Q9CZX9, Q9D1D9

UniProtKB/TrEMBL

A0A6P5PHT3, A0A8C6GMR7

Related

ENSMUSP00000028551.4, ENSMUST00000028551.4

Conserved Domains (1) summary

pfam06417
Location:56 → 170

DUF1077; Protein of unknown function (DUF1077)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

112193364..112209532 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252000.2 → XP_030107860.1 ER membrane protein complex subunit 4 isoform X1

UniProtKB/Swiss-Prot

Q9D1D9

UniProtKB/TrEMBL

A0A6P5PHT3, A0A8C6GMR7

Conserved Domains (1) summary

pfam06417
Location:56 → 170

DUF1077; Protein of unknown function (DUF1077)
XM_030251999.2 → XP_030107859.1 ER membrane protein complex subunit 4 isoform X1

UniProtKB/Swiss-Prot

Q9D1D9

UniProtKB/TrEMBL

A0A6P5PHT3, A0A8C6GMR7

Conserved Domains (1) summary

pfam06417
Location:56 → 170

DUF1077; Protein of unknown function (DUF1077)
XM_036162512.1 → XP_036018405.1 ER membrane protein complex subunit 4 isoform X2

Conserved Domains (1) summary

pfam06417
Location:1 → 89

DUF1077; Protein of unknown function (DUF1077)