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Emc4 ER membrane protein complex subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 68032, updated on 31-Jan-2023

Summary

Official Symbol
Emc4provided by MGI
Official Full Name
ER membrane protein complex subunit 4provided by MGI
Primary source
MGI:MGI:1915282
See related
Ensembl:ENSMUSG00000027131 AllianceGenome:MGI:1915282
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem85; 2610318K02Rik
Summary
Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to act upstream of or within apoptotic process. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is expressed in lung. Orthologous to human EMC4 (ER membrane protein complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 57.7), cortex adult (RPKM 48.8) and 28 other tissues See more
Orthologs
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Genomic context

See Emc4 in Genome Data Viewer
Location:
2; 2 E3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112193364..112209532, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112363019..112379476, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 6 Neighboring gene NOP10 ribonucleoprotein Neighboring gene predicted gene, 39908 Neighboring gene katanin p80 subunit B like 1 Neighboring gene ER membrane protein complex subunit 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to membrane insertase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of EMC complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ER membrane protein complex subunit 4
Names
transmembrane protein 85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026519.3NP_080795.1  ER membrane protein complex subunit 4

    See identical proteins and their annotated locations for NP_080795.1

    Status: PROVISIONAL

    Source sequence(s)
    AL683897
    Consensus CDS
    CCDS16553.1
    UniProtKB/Swiss-Prot
    Q9CZX9, Q9D1D9
    UniProtKB/TrEMBL
    A0A6P5PHT3, A0A8C6GMR7
    Related
    ENSMUSP00000028551.4, ENSMUST00000028551.4
    Conserved Domains (1) summary
    pfam06417
    Location:56170
    DUF1077; Protein of unknown function (DUF1077)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    112193364..112209532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252000.2XP_030107860.1  ER membrane protein complex subunit 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9D1D9
    UniProtKB/TrEMBL
    A0A6P5PHT3, A0A8C6GMR7
    Conserved Domains (1) summary
    pfam06417
    Location:56170
    DUF1077; Protein of unknown function (DUF1077)
  2. XM_030251999.2XP_030107859.1  ER membrane protein complex subunit 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9D1D9
    UniProtKB/TrEMBL
    A0A6P5PHT3, A0A8C6GMR7
    Conserved Domains (1) summary
    pfam06417
    Location:56170
    DUF1077; Protein of unknown function (DUF1077)
  3. XM_036162512.1XP_036018405.1  ER membrane protein complex subunit 4 isoform X2

    Conserved Domains (1) summary
    pfam06417
    Location:189
    DUF1077; Protein of unknown function (DUF1077)