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Tmem178 transmembrane protein 178 [ Mus musculus (house mouse) ]

Gene ID: 68027, updated on 26-Sep-2022

Summary

Official Symbol
Tmem178provided by MGI
Official Full Name
transmembrane protein 178provided by MGI
Primary source
MGI:MGI:1915277
See related
Ensembl:ENSMUSG00000024245 AllianceGenome:MGI:1915277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem178a; 2810417M05Rik
Summary
Involved in negative regulation of osteoclast differentiation and regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum membrane. Is expressed in cerebral cortex marginal layer; midbrain mantle layer; rest of cerebellum mantle layer; rest of cerebellum marginal layer; and ventral grey horn. Orthologous to human TMEM178A (transmembrane protein 178A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 35.6), cortex adult (RPKM 25.5) and 11 other tissues See more
Orthologs
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Genomic context

See Tmem178 in Genome Data Viewer
Location:
17; 17 E3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (81252061..81309245)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80944632..81001816)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C230072F16 gene Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene THUMP domain containing 2 Neighboring gene predicted gene, 53963

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026516.2NP_080792.2  transmembrane protein 178A precursor

    See identical proteins and their annotated locations for NP_080792.2

    Status: VALIDATED

    Source sequence(s)
    AC163903, AC165966, BX511370
    Consensus CDS
    CCDS37705.1
    UniProtKB/Swiss-Prot
    Q8CEU4, Q9CZ16
    UniProtKB/TrEMBL
    A0A6P5P0L9
    Related
    ENSMUSP00000025092.5, ENSMUST00000025092.5
    Conserved Domains (1) summary
    cl21598
    Location:106274
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    81252061..81309245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)