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STRN striatin [ Homo sapiens (human) ]

Gene ID: 6801, updated on 10-Oct-2019

Summary

Official Symbol
STRNprovided by HGNC
Official Full Name
striatinprovided by HGNC
Primary source
HGNC:HGNC:11424
See related
Ensembl:ENSG00000115808 MIM:614765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SG2NA; STRN1; PPP2R6A
Expression
Ubiquitous expression in esophagus (RPKM 6.7), brain (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See STRN in Genome Data Viewer
Location:
2p22.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (36837698..36966607, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (37064841..37193673, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2322 Neighboring gene vitrin Neighboring gene RNA, U6 small nuclear 577, pseudogene Neighboring gene HEAT repeat containing 5B Neighboring gene G-patch domain containing 11 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125642

Gene Ontology Provided by GOA

Function Evidence Code Pubs
armadillo repeat domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
armadillo repeat domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
bicellular tight junction assembly NAS
Non-traceable Author Statement
more info
PubMed 
dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
striatin
Names
protein phosphatase 2 regulatory subunit B'''alpha
striatin, calmodulin binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003162.4NP_003153.2  striatin

    See identical proteins and their annotated locations for NP_003153.2

    Status: VALIDATED

    Source sequence(s)
    AC007382, AC007404, AJ223814, AK026934
    Consensus CDS
    CCDS1784.1
    UniProtKB/Swiss-Prot
    O43815
    Related
    ENSP00000263918.4, ENST00000263918.9
    Conserved Domains (4) summary
    COG2319
    Location:429773
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:455779
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:48173
    Striatin; Striatin family
    sd00039
    Location:468514
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    36837698..36966607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533073.2XP_011531375.1  striatin isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:458802
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:484808
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:48173
    Striatin; Striatin family
    sd00039
    Location:497543
    7WD40; WD40 repeat [structural motif]
  2. XM_005264519.5XP_005264576.1  striatin isoform X2

    Related
    ENSP00000368513.2, ENST00000379213.3
    Conserved Domains (4) summary
    COG2319
    Location:392736
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:418742
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08232
    Location:48173
    Striatin; Striatin family
    sd00039
    Location:431477
    7WD40; WD40 repeat [structural motif]
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