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Defa20 defensin, alpha, 20 [ Mus musculus (house mouse) ]

Gene ID: 68009, updated on 8-Dec-2022

Summary

Official Symbol
Defa20provided by MGI
Official Full Name
defensin, alpha, 20provided by MGI
Primary source
MGI:MGI:1915259
See related
Ensembl:ENSMUSG00000095066 AllianceGenome:MGI:1915259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Defcr20; 2010016F14Rik
Summary
Involved in killing by host of symbiont cells. Acts upstream of or within antibacterial humoral response. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward large intestine adult (RPKM 3933.3) See more
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Genomic context

See Defa20 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (21999274..22000253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21509258..21510237)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MYM-type 5 pseudogene Neighboring gene defensin, alpha, pseudogene 17 Neighboring gene defensin, alpha, 32 Neighboring gene predicted gene, 24423

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables pore-forming activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-defensin 20
Names
cryptdin-4
cryptdin4
defensin-related cryptdin-20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183268.4NP_899091.2  alpha-defensin 20 precursor

    See identical proteins and their annotated locations for NP_899091.2

    Status: VALIDATED

    Source sequence(s)
    AK008275
    Consensus CDS
    CCDS40273.1
    UniProtKB/Swiss-Prot
    Q45VN2, Q8BH68
    Related
    ENSMUSP00000081055.4, ENSMUST00000084042.4
    Conserved Domains (2) summary
    pfam00323
    Location:6489
    Defensin_1; Mammalian defensin
    pfam00879
    Location:1551
    Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    21999274..22000253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)