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Nudt12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 [ Mus musculus (house mouse) ]

Gene ID: 67993, updated on 9-Feb-2019

Summary

Official Symbol
Nudt12provided by MGI
Official Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 12provided by MGI
Primary source
MGI:MGI:1915243
See related
Ensembl:ENSMUSG00000024228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610016O18Rik
Expression
Ubiquitous expression in liver adult (RPKM 3.4), kidney adult (RPKM 2.4) and 26 other tissues See more
Orthologs

Genomic context

See Nudt12 in Genome Data Viewer
Location:
17; 17 D
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (59000107..59013367, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (59140824..59152745, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene general transcription factor III A pseudogene Neighboring gene PDZ and pleckstrin homology domains 1 Neighboring gene predicted gene, 33751 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 12, opposite strand Neighboring gene nuclear encoded tRNA valine 3 (anticodon CAC) Neighboring gene zinc finger, BED domain containing 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD+ diphosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
NADH pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADH pyrophosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NAD catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
NADH metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADP catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
peroxisomal NADH pyrophosphatase NUDT12
Names
nucleoside diphosphate-linked moiety X motif 12
nudix (nucleoside diphosphnudix (nucleoside diphosphate linked moiety X)-type motif 12ate linked moiety X)-type motif 12
nudix motif 12
NP_080773.1
XP_006524898.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368393.1NP_001355322.1  peroxisomal NADH pyrophosphatase NUDT12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009564
  2. NM_026497.3NP_080773.1  peroxisomal NADH pyrophosphatase NUDT12 isoform 1

    See identical proteins and their annotated locations for NP_080773.1

    Status: VALIDATED

    Source sequence(s)
    AK002641, CT009564
    Consensus CDS
    CCDS28933.1
    UniProtKB/Swiss-Prot
    Q9DCN1
    Related
    ENSMUSP00000025065.5, ENSMUST00000025065.11
    Conserved Domains (7) summary
    COG2816
    Location:126457
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:1698
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03429
    Location:323457
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:147277
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:279302
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
    pfam13857
    Location:3186
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:1443
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    59000107..59013367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524835.3XP_006524898.1  peroxisomal NADH pyrophosphatase NUDT12 isoform X1

    Conserved Domains (6) summary
    COG2816
    Location:91294
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:1698
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03429
    Location:160294
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09297
    Location:116139
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
    pfam13857
    Location:3186
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:1443
    ANK; ANK repeat [structural motif]

RNA

  1. XR_876526.1 RNA Sequence

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