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Hormad1 HORMA domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 67981, updated on 8-Feb-2024

Summary

Official Symbol
Hormad1provided by MGI
Official Full Name
HORMA domain containing 1provided by MGI
Primary source
MGI:MGI:1915231
See related
Ensembl:ENSMUSG00000028109 AllianceGenome:MGI:1915231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nohma; 4921522K05Rik
Summary
Involved in several processes, including gamete generation; meiotic chromosome segregation; and regulation of cell cycle process. Acts upstream of or within homologous chromosome pairing at meiosis. Located in cytoplasm and synaptonemal complex. Is expressed in gonad. Orthologous to human HORMAD1 (HORMA domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 6.9) See more
Orthologs
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Genomic context

See Hormad1 in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95466988..95495174)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95559677..95587863)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7927 Neighboring gene predicted gene, 40096 Neighboring gene high mobility group box 1, pseudogene 5 Neighboring gene cathepsin S Neighboring gene STARR-positive B cell enhancer mm9_chr3:95392515-95392816 Neighboring gene predicted gene, 40097 Neighboring gene golgi phosphoprotein 3-like Neighboring gene ribosomal protein S10, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
HORMA domain-containing protein 1
Names
HORMA domain containing protein
newborn ovary HORMA protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289532.1NP_001276461.1  HORMA domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK014945, AK016743, AV259564, AW552644
    Consensus CDS
    CCDS71292.1
    UniProtKB/Swiss-Prot
    Q9CUF3, Q9D473, Q9D5T7
    Related
    ENSMUSP00000029754.7, ENSMUST00000029754.13
    Conserved Domains (1) summary
    pfam02301
    Location:27221
    HORMA; HORMA domain
  2. NM_001289534.1NP_001276463.1  HORMA domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_001276463.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AK016743, AV259564, AW552644, BC051129
    Consensus CDS
    CCDS38547.1
    UniProtKB/Swiss-Prot
    Q9D5T7
    Related
    ENSMUSP00000102772.2, ENSMUST00000107154.4
    Conserved Domains (1) summary
    pfam02301
    Location:24221
    HORMA; HORMA domain
  3. NM_001289537.1NP_001276466.1  HORMA domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_001276466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AK016743, AK163995, BC051129
    Consensus CDS
    CCDS38547.1
    UniProtKB/Swiss-Prot
    Q9D5T7
    Related
    ENSMUSP00000127180.2, ENSMUST00000171191.6
    Conserved Domains (1) summary
    pfam02301
    Location:24221
    HORMA; HORMA domain
  4. NM_001373886.1NP_001360815.1  HORMA domain-containing protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC092203
    UniProtKB/Swiss-Prot
    Q9CUF3, Q9D473, Q9D5T7
    Conserved Domains (1) summary
    pfam02301
    Location:27221
    HORMA; HORMA domain
  5. NM_026489.3NP_080765.1  HORMA domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_080765.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AK016743, AV259564, AW552644
    Consensus CDS
    CCDS38547.1
    UniProtKB/Swiss-Prot
    Q9D5T7
    Related
    ENSMUSP00000088303.5, ENSMUST00000090797.11
    Conserved Domains (1) summary
    pfam02301
    Location:24221
    HORMA; HORMA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95466988..95495174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)